Abstract: The present invention provides novel chlamydia antigens, nucleic acids encoding the antigens, and immunogenic compositions including the antigens. The present invention further provides methods of using the antigens to elicit immune responses (e.g., T cell-mediated and/or B cell-mediated immune responses). The present invention provides methods of prophylaxis and/or treatment of chlamydia-mediated diseases comprising administering an immunogenic composition including one or more of the novel antigens described herein.
Type:
Application
Filed:
October 20, 2011
Publication date:
May 31, 2012
Applicant:
GENOCEA BIOSCIENCES, INC.
Inventors:
Jessica Baker Flechtner, Kenya Prince Cohane, Todd Gierahn, Alexander Yao-Hsien Lee, George Rainer Siber
Abstract: Disclosed are novel chlamydia antigens, nucleic acids encoding the antigens, and immunogenic compositions including the antigens. Methods of using the antigens to elicit immune responses (e.g., T cell-mediated and/or B cell-mediated immune responses) comprising administering an immunogenic composition including one or more of the novel antigens may be used for prophylaxis and/or treatment of chlamydia-mediated diseases.
Type:
Application
Filed:
December 17, 2009
Publication date:
December 1, 2011
Applicant:
GENOCEA BIOSCIENCES, INC.
Inventors:
Kenya Cohane, Michele Picard, Todd Gierahn, Jessica Flechtner
Abstract: Herpes Simplex Virus-2 (HSV-2) infection is a major health concern. The present disclosure provides, inter alia, certain highly effective vaccines and immunogenic compositions against HSV-2. The antigens can be used therapeutically or prophylactically.