Abstract: The present invention relates to an isolated DNA sequence encoding a polypeptide having the biological activity of amorpha-4,11-diene synthase. This DNA sequence can be used for the transformation of bacteria, yeasts and plants for the production of amorpha-4,11-diene, a specific precursor in the synthesis of artemisinin, in the respective organisms. The invention also relates to these organisms.
Type:
Application
Filed:
July 18, 2006
Publication date:
February 8, 2007
Applicant:
GenoClipp Biotechnology B.V.
Inventors:
Thorvald Eelco Wallaart, Hendrik Jan Bouwmeester
Abstract: The present invention relates to an isolated DNA sequence encoding a polypeptide having the biological activity of amorpha-4,11-diene synthase. This DNA sequence can be used for the transformation of bacteria, yeasts and plants for the production of amorpha-4,11-diene, a specific precursor in the synthesis of artemisinin, in the respective organisms. The invention also relates to these organisms.
Type:
Grant
Filed:
August 27, 1999
Date of Patent:
August 15, 2006
Assignee:
GenoClipp Biotechnology B.V.
Inventors:
Thorvald Eelco Wallaart, Hendrik Jan Bouwmeester