Abstract: Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes since they are based on different electrostatic interactions between cationic poly(3-alkoxy-4-methylthiophene) derivatives and single-stranded or double-stranded (hybridized) oligonucleotides.
Type:
Application
Filed:
July 16, 2010
Publication date:
November 25, 2010
Applicant:
GENOM SCIENCES CANADA INC.
Inventors:
Mario Leclerc, Hoang Anh Ho, Maurice Boissinot