Abstract: The invention relates to a novel method used for deter-mining the aggressiveness and/or invasiveness of a tumor. The invention also relates to a method for identifying an anticancer agent that makes it possible to reduce the aggressiveness and/or invasiveness of a tumor. The invention is based on the inventors' findings that vimentin produced by the cancer cells can be a marker of the aggressiveness and/or invasiveness of a tumor. This maker capacity is not associated with expression of the vimentin in the cancer cells but is with a post-translational transformation of this different protein according to the degree of aggressiveness and/or invasiveness.
Type:
Application
Filed:
September 15, 2005
Publication date:
November 15, 2007
Applicant:
Genome Express SA
Inventors:
Ali Bouamrani, Emmamuel Gay, Jean-Paul Issartel, Francois Berger