Patents Assigned to Genome Therapeutics Corporation
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Patent number: 7285400Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: GrantFiled: December 10, 2003Date of Patent: October 23, 2007Assignees: Genome Therapeutics Corporation, Creighton UniversityInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
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Publication number: 20070037163Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: ApplicationFiled: July 30, 2004Publication date: February 15, 2007Applicant: Genome Therapeutics CorporationInventors: Lynn Doucette-Stamm, David Bush
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Publication number: 20070020624Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: ApplicationFiled: April 21, 2003Publication date: January 25, 2007Applicant: GENOME THERAPEUTICS CORPORATIONInventors: Marc Rubenfield, Jork Nolling, Craig Deloughery, David Bush
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Patent number: 7041814Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Enterobacter cloacae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: February 18, 1999Date of Patent: May 9, 2006Assignee: Genome Therapeutics CorporationInventors: Keith G. Weinstock, Craig Deloughery, David Bush
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Publication number: 20050142617Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: ApplicationFiled: April 29, 2004Publication date: June 30, 2005Applicants: Genome Therapeutics Corporation, Creighton University School of MedicineInventors: John Carulli, Randall Little, Robert Recker, Mark Johnson
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Patent number: 6800744Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumonia that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: June 30, 1998Date of Patent: October 5, 2004Assignee: Genome Therapeutics CorporationInventors: Lynn A. Doucette-Stamm, David Bush
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Publication number: 20040176582Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: ApplicationFiled: December 10, 2003Publication date: September 9, 2004Applicants: Genome Therapeutics Corporation, Creighton UniversityInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
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Patent number: 6780609Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: GrantFiled: April 5, 2000Date of Patent: August 24, 2004Assignee: Genome Therapeutics CorporationInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
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Patent number: 6770461Abstract: The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.Type: GrantFiled: April 5, 2000Date of Patent: August 3, 2004Assignees: Genome Therapeutics Corporation, Creighton University School of MedicineInventors: John P. Carulli, Randall D. Little, Robert R. Recker, Mark L. Johnson
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Patent number: 6747137Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Candida albicans that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from fungal infection.Type: GrantFiled: February 12, 1999Date of Patent: June 8, 2004Assignee: Genome Therapeutics CorporationInventors: Keith G. Weinstock, David Bush
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Patent number: 6737519Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.Type: GrantFiled: July 28, 2000Date of Patent: May 18, 2004Assignee: Genome Therapeutics CorporationInventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josèe Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
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Patent number: 6699703Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: May 26, 2000Date of Patent: March 2, 2004Assignee: Genome Therapeutics CorporationInventors: Lynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Eric Houseweart
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Patent number: 6683165Abstract: This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.Type: GrantFiled: April 13, 2000Date of Patent: January 27, 2004Assignee: Genome Therapeutics CorporationInventors: Tim Keith, Randall Little, Paul Van Eerdewegh, Josée Dupuis, Richard Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
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Publication number: 20040009583Abstract: A microtiter plate having at least one well and a lid having at least one insert which seals and reduces the volume of the well and methods of using the combination of the well and insert are described herein.Type: ApplicationFiled: February 5, 2003Publication date: January 15, 2004Applicant: Genome Therapeutics CorporationInventors: James A. Benn, Douglas R. Smith, Joseph D. Michienzi
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Patent number: 6673910Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Moracella catarrhalis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: April 4, 2000Date of Patent: January 6, 2004Assignee: Genome Therapeutics CorporationInventor: Gary L. Breton
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Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
Patent number: 6610836Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Klebsiella pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: January 27, 2000Date of Patent: August 26, 2003Assignee: Genome Therapeutics CorporationInventors: Gary L. Breton, Mark Osborne -
Nucleic acid and amino acid sequences relating to Proteus mirabilis for diagnostics and therapeutics
Patent number: 6605709Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Proteus fragilis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: April 5, 2000Date of Patent: August 12, 2003Assignee: Genome Therapeutics CorporationInventor: Gary L. Breton -
Patent number: 6583275Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived Enterococcus faecium that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: June 30, 1998Date of Patent: June 24, 2003Assignee: Genome Therapeutics CorporationInventors: Lynn A. Doucette-Stamm, David Bush
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Patent number: 6583266Abstract: Embodiments of the present invention feature nucleic acid and proteins derived from Mycobacterium tuberculosis and leprae. The proteins and nucleic acid of the present invention have applications in diagnostics and therapeutics.Type: GrantFiled: September 16, 1994Date of Patent: June 24, 2003Assignee: Genome Therapeutics CorporationInventors: Douglas R. Smith, Jen-i Mao
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Patent number: 6562958Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Acinetobacter mirabilis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.Type: GrantFiled: June 4, 1999Date of Patent: May 13, 2003Assignee: Genome Therapeutics CorporationInventors: Gary Breton, David Bush