Patents Assigned to Genomed
  • Patent number: 12270077
    Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids that have been fragmented with a transposase enzyme, alone or in combination with other types of analytes.
    Type: Grant
    Filed: July 6, 2023
    Date of Patent: April 8, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: Michael Schnall-Levin, Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Patrik Stahl, Jonas Frisen, Maja Marklund, Enric Llorens Bobadilla
  • Patent number: 12269036
    Abstract: Devices, systems, and their methods of use, for generating and collecting droplets are provided. The device includes a collection region comprising a side wall canted at an angle. The invention further provides multiplex devices that increase droplet formation.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: April 8, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: Ivan Akhremichev, Rajiv Bharadwaj, Lynna Chen, Mohammad Rahimi Lenji, Alireza Salmanzadeh, Martin Sauzade, Tobias Daniel Wheeler, Yiran Zhang
  • Patent number: 12265079
    Abstract: Disclosed are systems and methods for selecting biological particles (e.g., cells or nuclei) based on specific binding to a substrate and single-biological particle measurement of analytes from the substrate-bound biological particles (e.g., cells or nuclei). Single biological particles (e.g., cells or nuclei) from a population of biological particles are captured through their binding to biological particle- (e.g., cell- or nucleus-) and/or molecule-specific biological particle (e.g., cell or nucleus) capture moieties on a substrate. Analytes are released from the single captured biological particles (e.g., cells or nuclei) and bind to analyte-specific barcode molecules associated with the specific biological particle (e.g., cell or nucleus) capture moieties to which a biological particle (e.g., a cell or nucleus) has bound. Analysis of the barcode molecules identifies the bound analytes.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: April 1, 2025
    Assignee: 10x Genomics, Inc.
    Inventor: Zachary Bent
  • Patent number: 12263170
    Abstract: Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is LKB1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a G2/M checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising contacting the cancer cells with a therapeutically effective amount of a Wee1 inhibitor and a therapeutically effective amount of a second pharmaceutical composition.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: April 1, 2025
    Assignees: Dignity Health, The Translational Genomics Research Institute
    Inventors: Timothy G. Whitsett, Jr., Landon J. Inge
  • Patent number: 12263482
    Abstract: Devices, systems, and their methods of use, for sorting or separating magnetic particles are provided. A magnetic source is disposed adjacent a flow path and exerts a magnetic field on magnetic particles in order to separate particles.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: April 1, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: Alireza Salmanzadeh, Dagmar Walter
  • Publication number: 20250101485
    Abstract: Disclosed herein are metabolically engineered cells capable of producing carotenoids from acid whey.
    Type: Application
    Filed: January 26, 2023
    Publication date: March 27, 2025
    Applicants: Massachusetts Institute of Technology, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences
    Inventors: Gregory Stephanopoulos, Yongshou Ma, Konstantinos Katsimpouras, Junichi Mano, Adrian Fay
  • Patent number: 12256764
    Abstract: Supplemental food formulations are described herein that can contain various nutrients, including at least four of the following: amino acid blend, fulvic-humic acids, multi-minerals, glycerin, phosphatidylinositol, sesquiterpene alkaloids, terpenes, medium-chain triglycerides (MCTs), coconut oil, whole plant matter, plant seeds, mushrooms, seaweeds, kelp, and flavoring agents.
    Type: Grant
    Filed: March 31, 2023
    Date of Patent: March 25, 2025
    Assignee: CG-Bio Genomics, Inc.
    Inventors: William C. Carrington, Marc J. George
  • Patent number: 12258624
    Abstract: The present disclosure relates in some aspects to methods and compositions for in situ analysis involving catalytic de-crosslinking of biological samples.
    Type: Grant
    Filed: October 31, 2023
    Date of Patent: March 25, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: Joshua Delaney, Shalini Gohil, Veronica Emelina Gonzalez Muñoz, Joshua Gu, Albert Dale Kim, Yi Luo, Tathagata Mukherjee, Monica Nagendran, James Francis Perna, III, Kristen Nguyen Pham, Meiliana Tjandra
  • Patent number: 12258623
    Abstract: Disclosed herein, inter alia, are devices, compositions, kits, and methods for interrogating biological samples.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: March 25, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Eli N. Glezer, Christopher Frye
  • Patent number: 12252740
    Abstract: A device comprising: a sample stage configured to be coupled to a microplate receiver; a microplate receiver configured to be coupled to a microplate; at least one heating element thermally coupled to the microplate receiver; a fluidics dispenser configured to dispense one or more reagents into the microplate; and an imaging system configured to detect one or more features in the microplate; and a structure physically coupled to the sample stage, the heating element, the fluidics dispenser, and the imaging system.
    Type: Grant
    Filed: July 14, 2023
    Date of Patent: March 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Eli N. Glezer, Christopher Frye
  • Patent number: 12252732
    Abstract: The present disclosure provides methods and systems for nucleic acid preparation and/or analysis. Nucleic acids may be derived from one or more cells. Nucleic acid preparation may comprise generating nucleic acid molecules of varying lengths. Nucleic acid analysis may comprise identifying nucleic acid sequence information with nucleosome position information.
    Type: Grant
    Filed: June 21, 2023
    Date of Patent: March 18, 2025
    Assignee: 10x Genomics, Inc.
    Inventor: Geoffrey McDermott
  • Patent number: 12247253
    Abstract: The invention generally relates to sequencing library preparation methods. In certain embodiments, two template nucleic acids are joined together by a linking molecule, such as a PEG derivative. The linked template nucleic acids is amplified, creating linked amplicons.
    Type: Grant
    Filed: August 1, 2024
    Date of Patent: March 11, 2025
    Assignee: NCAN Genomics, Inc.
    Inventors: Milenko Despotovic, Joel Pel, Andrea Marziali
  • Patent number: 12246326
    Abstract: Provided herein are devices and methods for securing microplates and/or microplates comprising tube strips. The devices provided herein may use a magnetic force to secure the microplates and/or the tube strips during heat sealing of wells or tubes.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: March 11, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: David Maurice Cox, Stefanie Nishimura, Lauren Wong
  • Patent number: 12247921
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for rapidly identifying and/or quantifying features.
    Type: Grant
    Filed: May 10, 2023
    Date of Patent: March 11, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • Patent number: 12249085
    Abstract: A method for aligning a sample to an array is provided. An image of sample image of a sample can be received by a data processor. The sample image having a first resolution. An array image including an overlay of an array with the sample and an array fiducial can be received by the data processor. The array image having a second resolution lower than the first resolution of the sample image. The sample image can be registered to the array image by aligning the sample image and the array image. An aligned image can be generated based on the registering. The aligned image can include an overlay of the sample image with the array. The aligned image can be provided by the data processor. A method for detecting fiducials associated with an array is provided. Systems and non-transitory computer readable mediums performing the method are also provided.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: March 11, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: Augusto Manuel Tentori, Hanyoup Kim, Siyuan Xing, Felice Alessio Bava, Rajiv Bharadwaj, Cedric Uytingco, Erica Graziosa
  • Patent number: 12241890
    Abstract: The present disclosure provides compositions and methods for using fixed biological samples in partition-based assays. In at least one embodiment, the disclosure provides a composition comprising a fixed biological sample and an un-fixing agent contained in a partition, such as a discrete droplet. In some embodiments, the disclosure provides un-fixing agent compounds capable of catalytically cleaving crosslinks in fixed biological samples, particularly crosslinked nucleic acids, such as RNA.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: March 4, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: Joshua Delaney, Shalini Gohil, Jill Herschleb, Adam Lowe, Albert Kim, Meiliana Tjandra
  • Patent number: D1066732
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: March 11, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka
  • Patent number: D1066735
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: March 11, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka
  • Patent number: D1067462
    Type: Grant
    Filed: October 30, 2023
    Date of Patent: March 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka
  • Patent number: D1069162
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: April 1, 2025
    Assignee: 10x Genomics, Inc.
    Inventor: Dongyao Li