Patents Assigned to Genomembrane, Inc.
  • Transporter protein in mammal and utilization of the same
    Patent number: 8278032
    Abstract: The present invention provides a lipid membrane that contains a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, or 22. Use of the present invention enables screening for a chemical which regulates excretion of a chemical and/or a waste. Furthermore, use of the present invention enables an arbitrary chemical to be tested for nephrotoxicity and/or hepatotoxicity.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: October 2, 2012
    Assignee: Genomembrane, Inc.
    Inventors: Yoshinori Moriyama, Hiroshi Omote, Masato Otsuka, Takuya Matsumoto, Miki Hiasa
  • Transporter protein in mammal and utilization of the same
    Patent number: 7892728
    Abstract: The present invention provides a lipid membrane that contains a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, or 22. Use of the present invention enables screening for a chemical which regulates excretion of a chemical and/or a waste. Furthermore, use of the present invention enables an arbitrary chemical to be tested for nephrotoxicity and/or hepatotoxicity.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: February 22, 2011
    Assignee: Genomembrane, Inc.
    Inventors: Yoshinori Moriyama, Hiroshi Omote, Masato Otsuka, Takuya Matsumoto, Miki Hiasa
  • Novel Transporter Protein in Mammal and Utilization of the Same
    Publication number: 20100279331
    Abstract: The present invention provides a lipid membrane that contains a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, or 22. Use of the present invention enables screening for a chemical which regulates excretion of a chemical and/or a waste. Furthermore, use of the present invention enables an arbitrary chemical to be tested for nephrotoxicity and/or hepatotoxicity.
    Type: Application
    Filed: June 17, 2010
    Publication date: November 4, 2010
    Applicant: Genomembrane, Inc.
    Inventors: Yoshinori Moriyama, Hiroshi Omote, Masato Otsuka, Takuya Matsumoto, Miki Hiasa
  • Novel Transporter Protein in Mammal and Utilization of the Same
    Publication number: 20090042219
    Abstract: The present invention provides a lipid membrane that contains a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, or 22. Use of the present invention enables screening for a chemical which regulates excretion of a chemical and/or a waste. Furthermore, use of the present invention enables an arbitrary chemical to be tested for nephrotoxicity and/or hepatotoxicity.
    Type: Application
    Filed: October 12, 2006
    Publication date: February 12, 2009
    Applicant: GENOMEMBRANE, INC.
    Inventors: Yoshinori Moriyama, Hiroshi Omote, Masato Otsuka, Takuya Matsumoto, Miki Hiasa
  • Method of screening remedy for breast cancer
    Publication number: 20070148703
    Abstract: The present invention is a method for screening a remedy for breast cancer which does not require uptake into cells unlike aromatase inhibitors, estrogen sulfatase inhibitors, or estrogen competitive inhibitors such as tamoxifen and toremifene, and which shows excellent drug delivery property and extremely rare adverse effect. In the method, a remedy for breast cancer which inhibits transporter function is screened by the process comprising the steps of: culturing a cultured human breast cancer cell line such as MCF-7 cell line or T-47D cell line in the presence of estrone-3-sulfate and a test substance such as bromosulfophtalein; and evaluating whether the uptake of estrone-3-sulfate into cells via estrone-3-sulfate transporters expressed on the cell surface is inhibited, and whether the proliferation of MCF-7 cell line is suppressed.
    Type: Application
    Filed: June 18, 2004
    Publication date: June 28, 2007
    Applicant: Genomembrane, Inc.
    Inventors: Ikumi Tamai, Takashi Nozawa