Abstract: The present invention, called Physical Characterization of Telomere (PCT), provides and advantageous, accurate and convenient new methods for the visualization, characterization and measurements of telomere sequences. It employs probes and dyes to create a pattern of physical images, classifies the images, and determines the lengths of telomere sequences. PCT brings to a deeper understanding of telomere modifications that occur either genome wide manner or in a chromosome specific way.
Type:
Application
Filed:
November 23, 2021
Publication date:
May 26, 2022
Applicant:
GENOMIC VISION SA
Inventors:
Prakhar BISHT, Mario Davide Maria AVARELLO, Engin ALTUNLU, Andrii KULAKOVSKYI, Aaron BENSIMON
Abstract: Methods for detecting and characterizing large genomic rearrangements induced by modified nucleases at high resolution and for quantifying the frequency of the large genomic or gene rearrangements induced by modified nucleases using Molecular Combing.
Abstract: An automated, computer-implemented method for detecting and measuring large amounts of data obtained from molecular combing procedures including the identification and characterization of seven different DNA replication initiation and termination patterns.
Type:
Application
Filed:
October 15, 2018
Publication date:
April 18, 2019
Applicant:
GENOMIC VISION SA
Inventors:
Jeremie NICOLLE, Vincent GLAUDIN, Ivan KYRGYZOV, Aaron BENSIMON
Abstract: Methods for detecting and characterizing large genomic rearrangements induced by modified nucleases at high resolution and for quantifying the frequency of the large genomic or gene rearrangements induced by modified nucleases using Molecular Combing.
Abstract: Methods and products for detecting in vitro the presence of damage on DNA or the presence of a biological response to damage on DNA at the molecular level. Molecular Combing or other nucleic acid stretching methods are employed together with compounds reacting with DNA, probes binding DNA, or nucleic acid monomers, especially labeled nucleic acid monomers.