Abstract: It has been found that a urine test for ovarian reserve can be provided which is equivalent in sensitivity to current laboratory methods which determine ovarian reserve based on FSH levels in serum. A lateral flow device for indicating ovarian reserve is disclosed. The device has an application zone for receiving a urine sample, a labelling zone containing label which binds to FSH in the sample, and a detection zone where FSH-bound label is retained. The detection zone has a threshold value which corresponds to a serum FSII level of between 5-20 mIU/ml (e.g. 10 mIU/ml). A test result above the threshold value indicates diminished ovarian reserve.

Abstract: Device (1) for assaying a particulate analyte, comprising (a) a receptacle (2) for receiving a suspension (5) of particulate analyte, and containing label (3) for the particulate analyte, and (b) a porous detection material (4) that is permeable to label (3) but is impermeable to particulate analyte, the detection material (4) being arranged within receptacle (2) such that introduction of suspension (5) of particulate analyte into receptacle (2) forms liquid communication between label (3) and detection material (4). After liquid sample (5) is introduced into the receptacle (2), capillary flow through the porous detection material (4) begins. Particulate analyte cannot flow through the detection material (4) and is captured at its surface. Addition of liquid sample (5) also releases the label (3) within the receptacle (2), which is then free to flow through the detection material (4). Label (3) encounters the captured analyte and gives a signal (7).

Abstract: An apparatus for separating and detecting motile spermatozoa in a liquid sample, comprises: a separation vessel including (i) an inlet port, (ii) an outlet port arranged to be opened, (iii) a separation medium into which motile spermatozoa in the sample can flow via the inlet port, and (iv) an actuator operable to open the outlet port for allowing the separation medium to flow out of the vessel through the outlet port; and a spermatozoa detection device including (i) an application zone in communication with the outlet port, (ii) a detection zone, in which presence of spermatozoa can be detected, and (iii) a reagent zone containing a reagent which is capable of reacting with spermatozoa to facilitate detection of the spermatozoa in the detection zone, with the application zone, the detection zone and the reagent zone being arranged to permit capillary flow of spermatozoa from the application zone to the detection zone.