Abstract: The present invention is directed to novel recombinant nucleic acids for introducing yeast chromosomal elements into the genomes of bacteria. The invention provides methods to convert the modified bacterial genomes into artificial yeast chromosomes by fusing the bacteria with yeast that linearize the modified bacterial genomes, to produce artificial chromosomes.
Type:
Grant
Filed:
August 6, 2003
Date of Patent:
August 10, 2010
Assignee:
Genotypes, Inc.
Inventors:
Ronald A. Hitzeman, George E. Chisholm, IV
Abstract: The invention discloses methods for effecting the production of recombinant mammalian procollagen in yeast, as well as compositions comprising yeast cells cap producing mammalian procollagen.
Type:
Grant
Filed:
July 22, 1998
Date of Patent:
October 29, 2002
Assignees:
Cohesion Technologies, Inc., Genotypes, Inc.
Inventors:
David P. Toman, Gregory A. Daniels, Richard A. Berg, Ronald A. Hitzeman, George E. Chisholm
Abstract: Methods are disclosed for simplified recombinant production of fibrillar collagens. DNAs encoding fibrillar collagen monomers lacking the N propeptide, the C propeptide, or both propeptides are introduced into recombinant host cells and expressed. Trimeric collagen is recovered from the recombinant host cells.
Type:
Grant
Filed:
April 9, 1999
Date of Patent:
August 6, 2002
Assignees:
Cohesion Technologies, Inc., Genotypes, Inc.
Inventors:
David R. Olsen, Robert Chang, Hugh McMullin, Ronald A. Hitzeman, George Chisholm
Abstract: Methods are disclosed for simplified recombinant production of fibrillar collagens. DNAs encoding fibrillar collagen monomers lacking the N propeptide, the C propeptide, or both propeptides are introduced into recombinant host cells and expressed. Trimeric collagen is recovered from the recombinant host cells.
Type:
Grant
Filed:
May 31, 2000
Date of Patent:
July 2, 2002
Assignees:
Cohesion Technologies, Inc., Genotypes, Inc.
Inventors:
David R. Olsen, Robert Chang, Hugh McMullin, Ronald A. Hitzeman, George Chisholm
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