Abstract: Methods of preventing the transmission of a mitochondrial disease, disorder, or condition using mitochondria-targeted enzymes or mRNA encoding mitochondria-targeted enzymes. The methods as described herein can specifically eliminate mitochondrial DNA (mtDNA) mutations in the germline.
Type:
Application
Filed:
April 15, 2016
Publication date:
October 20, 2016
Applicant:
GenOva Laboratories LLC
Inventors:
Juan Carlos Izpisua Belmonte, Pradeep Reddy Dubbaka Venu, Alejandro Ocampo, Keiichiro Suzuki, Yuji Tsunekawa