Patents Assigned to Genpharm Internation, Inc.
  • Methods for producing recombinant mammalian cells harboring a yeast artificial chromosome
    Patent number: 5981175
    Abstract: The present invention provides methods and compositions for transferring large transgene polynucleotides and unlinked selectable marker polynucleotides into eukaryotic cells by a novel method designated co-lipofection. The methods and compositions of the invention are used to produce novel transgenic non-human animals harboring large transgenes, such as a transgene comprising a human APP gene or human immunoglobulin gene.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: November 9, 1999
    Assignee: Genpharm Internation, Inc.
    Inventors: Jeanne F. Loring, Theodore Choi, Robert M. Kay