Abstract: Provided are a medical ointment of a novel combination containing paeonol and a pharmaceutical use thereof. The medical ointment of a novel combination includes paeonol and panthenol, and further includes at least one selected from Centella asiatica, coenzyme Q10, neomycin sulfate, and pharmaceutically acceptable salts of these. In the medical ointment of a novel combination, specific ingredients that are effective for local pain relief are mixed with ingredients having other effects in a certain ratio to address the problems of the cut treatment ointment of the related art, so that excellent effects may be obtained in relieving itching and reducing pain while inflammation is effectively treated.