Patents Assigned to Genzyme Corporation
  • Publication number: 20230158058
    Abstract: The invention relates to iRNA, e.g., double stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to treat a bleeding event in a subject having a hemophilia (e.g., with or without inhibitors).
    Type: Application
    Filed: August 1, 2022
    Publication date: May 25, 2023
    Applicant: Genzyme Corporation
    Inventor: Akin Akinc
  • Publication number: 20230144192
    Abstract: The present disclosure provides methods for treating and improving b1osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of an agent that binds and neutralizes transforming growth factor beta (TGF-?).
    Type: Application
    Filed: October 31, 2022
    Publication date: May 11, 2023
    Applicant: Genzyme Corporation
    Inventors: Panteleimon D. MAVROUDIS, Nikhil PILLAI, Qingping WANG
  • Publication number: 20230135379
    Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.
    Type: Application
    Filed: November 10, 2022
    Publication date: May 4, 2023
    Applicant: Genzyme Corporation
    Inventors: Marco A. PASSINI, Lamya Shihabuddin, Seng H. Cheng
  • Patent number: 11639887
    Abstract: Provided herein are methods to characterize preparations of recombinant viral particles using analytical ultracentrifugation. Recombinant viral particles include recombinant adeno-associated viral particles, recombinant adenoviral particles, recombinant lentiviral particles and recombinant herpes simplex virus particles. Variant species of recombinant viral particles including empty capsids and recombinant viral particles with variant genomes (e.g., truncated genomes, aggregates, recombinants) can be identified and quantitated. The methods can be used to characterize preparations of recombinant viral particles regardless of the sequence of the recombinant viral genome or the serotype of the recombinant viral capsid.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: May 2, 2023
    Assignee: Genzyme Corporation
    Inventors: Catherine R. O'Riordan, Brenda Burnham
  • Publication number: 20230126645
    Abstract: Described herein are compositions of Thyroid Stimulating Hormone (TSH), wherein at least one polyalkylene glycol polymer is attached to a carbohydrate site of the TSH. Also described are compositions of mutated Thyroid Stimulating Hormone (TSH) and at least one polyalkylene glycol polymer, wherein the mutated TSH comprises a TSH in which one or more amino acid residues has been substituted with cysteine residue, and the polyalkylene glycol polymer is attached to the mutated TSH at the site of the substituted cysteine residue. Pharmaceutical compositions comprising these TSH compositions and method of treating a thyroid condition in a patient in need thereof, by administering to the patient an effective amount of the pharmaceutical compositions are also described.
    Type: Application
    Filed: May 23, 2022
    Publication date: April 27, 2023
    Applicant: GENZYME CORPORATION
    Inventors: Clark PAN, Huawei QIU, Sunghae PARK
  • Patent number: 11635363
    Abstract: Provided herein are methods and compositions for batch production of producer cells using fluorescence activated cell sorting (FACS). In some aspects, the disclosure provides a drug-selection-free method for batch production of producer cells using FACS. Such batch production methods and compositions can be further utilized to generate clonal populations of producer cells, e.g., for large-scale manufacturing of a polypeptide of interest.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: April 25, 2023
    Assignee: GENZYME CORPORATION
    Inventors: Victor R. Cairns, Jose Ignacio Sancho Chavida, Christine DeMaria
  • Publication number: 20230078449
    Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGF?) and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGF?1, TGF?2 and TGF?3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
    Type: Application
    Filed: September 16, 2022
    Publication date: March 16, 2023
    Applicants: Genzyme Corporation, Optein, Inc.
    Inventors: Steven R. Ledbetter, Celia Patricia Hart, Robert G. Holgate, Lutz U. Jermutus, Catriona L. Buchanan, Alexander R. Duncan, Donna K. Finch
  • Publication number: 20230084580
    Abstract: Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.
    Type: Application
    Filed: October 13, 2022
    Publication date: March 16, 2023
    Applicant: Genzyme Corporation
    Inventors: Marco A. PASSINI, Lamya Shihabuddin, Seng H. Cheng
  • Patent number: 11603529
    Abstract: Provided herein are RNAi molecules for treating Huntington's disease. Further provided herein are expression cassettes, vectors (e.g., rAAV, recombinant adenoviral, recombinant lentiviral, and recombinant HSV vectors), cells, viral particles, and pharmaceutical compositions containing the RNAi. Yet further provided herein are methods and kits related to the use of the RNAi, for example, to treat Huntington's disease.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: March 14, 2023
    Assignee: GENZYME CORPORATION
    Inventors: Catherine R. O'Riordan, Adam Palermo, Brenda Richards, Lisa M. Stanek
  • Publication number: 20230036928
    Abstract: The present disclosure provides pharmaceutical compositions comprising anti-TGF-? antibodies and methods of use thereof.
    Type: Application
    Filed: June 17, 2022
    Publication date: February 2, 2023
    Applicant: Genzyme Corporation
    Inventors: Kiran Rana BANGARI, Ramil LATYPOV, Timothy MCCOY, Sanket PATKE
  • Patent number: 11554161
    Abstract: This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: January 17, 2023
    Assignee: Genzyme Corporation
    Inventors: James Dodge, Lamya Shihabuddin, Catherine O'Riordan
  • Patent number: 11530216
    Abstract: Disclosed herein are deuterated compounds of the formula which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: December 20, 2022
    Assignee: GENZYME CORPORATION
    Inventors: John L. Kane, Jr., Nellwyn A. Hagan, Maria A. Fitzgerald
  • Publication number: 20220396588
    Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).
    Type: Application
    Filed: February 9, 2022
    Publication date: December 15, 2022
    Applicant: Genzyme Corporation
    Inventors: John L. Kane, JR., Claude Barberis, Mark Czekaj, Paul Erdman, Barret Giese, Michael Kothe, Tieu-Binh Le, Jinyu Liu, Liang Ma, Markus Metz, Vinod Patel, Andrew Scholte, Patrick Shum, Linli Wei
  • Publication number: 20220370653
    Abstract: The present technology relates to a novel sanitization method for chromatography media and supporting equipment comprising treatment with a sanitization/sterilization solution comprising acetic acid and hexylene glycol.
    Type: Application
    Filed: May 6, 2022
    Publication date: November 24, 2022
    Applicant: GENZYME CORPORATION
    Inventors: Joseph P. Kutzko, Ryan F. Wollensak
  • Patent number: 11505611
    Abstract: Anti-FGFR3 antigen-binding proteins and antigen-binding binding fragments thereof are provided. Methods of inhibiting FGFR3 activity and methods of treating FGFR3-mediated diseases and disorders are also provided.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: November 22, 2022
    Assignee: GENZYME CORPORATION
    Inventors: Yves Sabbagh, Yangde Chen, William Brondyk, Huawei Qiu, Sunghae Park, Ronnie Wei, Yu Qiu, Yanfeng Zhou, Cendrine Lemoine, HyunSuk Cho
  • Patent number: 11504713
    Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: November 22, 2022
    Assignee: Genzyme Corporation
    Inventors: Tarl Vetter, Kevin Brower
  • Publication number: 20220363740
    Abstract: An scFv-Fc dimer binds and neutralizes TGF?1 selectively and with high affinity and avidity. The scFv region may comprise the same VH and VL domains or CDR regions as metelimumab. The unique combination of their smaller size, high selectivity, potency against TGF?1, and long in vivo half-life makes the scFv-Fc dimers ideal candidates for therapeutic applications.
    Type: Application
    Filed: April 4, 2022
    Publication date: November 17, 2022
    Applicant: GENZYME CORPORATION
    Inventors: Huawei Qiu, Clark Pan, Julie Bird
  • Publication number: 20220315649
    Abstract: A modified IgG antibody binds and neutralizes TGF?1 selectively and with high affinity and avidity. The modified IgG antibody comprises four polypeptide chains and may comprise modifications to the elbow regions of the polypeptide chains. The modified IgG antibody may comprise the same VH and VL domains or CDR regions as metelimumab. The modified IgG anti-body is useful in therapeutic and diagnostic applications.
    Type: Application
    Filed: April 11, 2022
    Publication date: October 6, 2022
    Applicant: Genzyme Corporation
    Inventors: Huawei Qiu, Julie Bird
  • Patent number: 11458119
    Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: October 4, 2022
    Assignee: GENZYME CORPORATION
    Inventors: Hanlan Liu, Chris Willis, Renu Bhardwaj, Jianmei Kochling, Craig Siegel
  • Publication number: 20220305091
    Abstract: The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B.
    Type: Application
    Filed: February 18, 2022
    Publication date: September 29, 2022
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, GENZYME CORPORATION
    Inventors: Edward H. Schuchman, Robert J. Desnick, Gerald F. Cox, Laura P. Andrews, James M. Murray