Patents Assigned to Genzyme Glycobiology Research Institute, Inc.
  • GLCNAC PHOSPHOTRANSFERASE OF THE LYSOSOMAL TARGETING PATHWAY
    Publication number: 20080176285
    Abstract: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.
    Type: Application
    Filed: February 27, 2008
    Publication date: July 24, 2008
    Applicant: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. CANFIELD
  • GIcNAc phosphotransferase of the lysosomal targeting pathway
    Patent number: 7067127
    Abstract: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: June 27, 2006
    Assignee: Genzyme Glycobiology Research Institute Inc.
    Inventor: William M. Canfield
  • GlcNAc phosphotransferase of the lysosomal targeting pathway
    Publication number: 20060073498
    Abstract: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.
    Type: Application
    Filed: August 9, 2005
    Publication date: April 6, 2006
    Applicant: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William Canfield
  • Soluble GlcNAc phosphotransferase
    Publication number: 20050170449
    Abstract: The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same.
    Type: Application
    Filed: January 31, 2005
    Publication date: August 4, 2005
    Applicant: Genzyme Glycobiology Research Institute, Inc.
    Inventors: William Canfield, Mariko Kudo
  • Soluble GlcNAc phosphotransferase
    Patent number: 6905856
    Abstract: The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: June 14, 2005
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventors: William Canfield, Mariko Kudo
  • Methods for producing highly phosphorylated lysosomal hydrolases
    Patent number: 6861242
    Abstract: The present invention provides highly phosphorylated lysosomal hydrolases, methods of modifying lysosomal hydrolases with the lysosomal targeting pathway enzymes GlcNAc-phosphotransferase and/or phosphodiester ?-GlcNAcase.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: March 1, 2005
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. Canfield
  • Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester alpha-N-acetyl glucosimanidase
    Publication number: 20050003486
    Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester ? N-acetyl glucosimanidase (phosphodiester ?-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal bydrolases having an N-acetylglucosamine-1-phosphate.
    Type: Application
    Filed: July 29, 2004
    Publication date: January 6, 2005
    Applicant: Genzyme Glycobiology Research Institute, Inc.
    Inventors: William Canfield, Stuart Kornfeld
  • Phosphodiester &agr;-GlcNAcase of the lysosomal targeting pathway
    Patent number: 6828135
    Abstract: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme phosphodiester &agr;-GlcNAcase, methods of producing and methods of purifying this enzyme.
    Type: Grant
    Filed: November 29, 2002
    Date of Patent: December 7, 2004
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. Canfield
  • Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester &agr;-N-acetyl glucosimanidase
    Patent number: 6800472
    Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester &agr; N-acetyl glucosimanidase (phosphodiester &agr;-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal hydrolases having an N-acetylglucosamine-1-phosphate.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: October 5, 2004
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventors: William Canfield, Stuart Kornfeld
  • Phosphodiester-a-GlcNAcase of the lysosomal targeting pathway
    Patent number: 6770468
    Abstract: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme phosphodiester &agr;-GlcNAcase, methods of producing and methods of purifying this enzyme.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: August 3, 2004
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. Canfield
  • Methods for producing highly phosphorylated lysosomal hydrolases
    Patent number: 6670165
    Abstract: The present invention provides highly phosphorylated lysosomal hydrolases, methods of modifying lysosomal hydrolases with the lysosomal targeting pathway enzymes GlcNAc-phosphotransferase and/or phosphodiester &agr;-GlcNAcase.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: December 30, 2003
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. Canfield
  • GlcNAc phosphotransferase of the lysosomal targeting pathway
    Patent number: 6642038
    Abstract: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: November 4, 2003
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. Canfield
  • Methods of treating lysosomal storage diseases
    Patent number: 6537785
    Abstract: The present invention provides methods of treating lysosomal storage disease with highly phosphorylated lysosomal hyrdrolases.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: March 25, 2003
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. Canfield
  • Methods for producing highly phosphorylated lysosomal hydrolases
    Patent number: 6534300
    Abstract: The present invention provides highly phosphorylated lysosomal hydrolases, methods of modifying lysosomal hydrolases with the lysosomal targeting pathway enzymes GlcNAc-phosphotransferase and/or phosphodiester &agr;-GlcNAcase.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: March 18, 2003
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventor: William M. Canfield