Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.

Abstract: The present disclosure generally relates to classes of compounds that bind the chromo-barrel domain of AT-rich interactive domain 4B (ARID4B). In some aspects, the compounds are of the Formula (II) as described herein, or a diamine composite thereof as set forth in Formula III herein. In some aspects, the compound is selected from compounds 1a, 1b, 1c, 1d, 1e, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, (as described herein) or combinations thereof. The present disclosure further considers administration of the compounds to target ARID4B in cells and for the treatment of cancerous breast tissue cells.

Abstract: Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to one or more anticancer drugs, such as platinum-based chemotherapeutics.

Abstract: Systems and methods are disclosed for improving on-chip security, while minimizes the latency and cost of security techniques to improve system-level performance and power simultaneously. The framework uses machine learning algorithms, such as an artificial neural network (ANN), for runtime attack detection with higher accuracy. Further, a learning-based attack mitigation method using deep reinforcement learning is disclosed, where the method may be used to isolate the malicious components and to optimize network latency and energy-efficiency.

Abstract: Systems and methods are disclosed for air flow optimization. In certain embodiments, the technology is a system comprising sensors, injectors, actuators, and a system processor. In order to optimize the air flow, the system processor directs the injectors to expel aerosol particles into an environment, such that the aerosol particles can be measured by the one or more sensors. Flow intensity map generation is then used to map the aerosol particles and air flow is changed to optimize aerosol particle concentration using the actuators.

Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for preventing or slowing the spread of a viral infection, wherein optionally the viral infection is a coronavirus infection, optionally a COVID-19 infection or variant thereof, or a human immunodeficiency virus (HIV) infection, preventing or decreasing coronavirus or HIV-co-morbidities in an individual, or inhibiting, or slowing the rate of, coronavirus (optionally COVID-19) or HIV replication in vitro and in vivo.

Abstract: The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising obtaining a biological sample rom said subject; detecting RNA expression levels of at least three or more biomarkers in the biological sample and comparing the expression levels of said at least three or more biomarkers to a control sample wherein an increase or decrease in the level of expression of said at least three or more biomarkers as compared to the control sample is indicative of appendicitis.

Abstract: A cyber-physical system for conducting a telehealth session. In embodiments, the system includes a hardware control box that enables patients (e.g., elderly or cognitively-impaired patients) to easily participate in the telehealth session. In some embodiments, the system analyzes sensor data (e.g., thermal images, eye tracking data, etc.) and calculates state variables that form a mathematical representation (a “digital twin”) indicative of the physical, emotive, cognitive, or social state of the patient. In some of those embodiments, the system calculates Myasthenia Gravis core examination metrics by performing computer vision analysis on patient video data and/or audio analysis on patient audio data. In some embodiments, the system controls a pan-tile-zoom camera to zoom in on each region of interest that is relevant to the examination.

Abstract: The present disclosure relates to an improved process for the synthesis of hydrogen terminated silicon from Zintl phases. The hydrogen terminated silicon is useful, for example, as explosives, chemical and biochemical sensors, optoelectronic materials and Li-ion battery anode ion storage materials. The present disclosure also relates to an improved process for the synthesis of nanomaterials and composites from Zintl phases. The nanomaterials and composites are useful, for example, as ion storage materials.

Abstract: The present disclosure relates to improved processes for preparing modified lignite by reacting raw lignite with a source of magnesium (Mg2+) ions and a source of calcium (Ca2+) ions, washing the modified lignite (e.g., with water), drying, and pyrolyzing the treated lignite, and to the use of such products for phosphorous remediation.

Abstract: Catalysts and methods for transformation of glycerol and a carbon feedstock, such as CO2, a carbonate salt or a bicarbonate salt, are described herein. Homogeneous catalysts include compounds of formula M[NHC-R-linker]aLbXc, where M is a transition metal, NHC is an N-heterocyclic carbene ligand, R is an alkyl or aryl group, linker is a polar group, L is a neutral ligand, X is an anionic ligand, a ranges from 1-3, b ranges from 0-3, and c ranges from 0-3. Heterogeneous catalysts include a solid support with a catalytically active compound immobilized on the solid support, where the catalytically active compound has the formula M[NHC-R-linker]aLbXc where M is a transition metal, NHC is an N-heterocyclic carbene ligand, R is an alkyl or aryl group; linker is a polar group, L is a neutral ligand, X is an anionic ligand, a ranges from 1-3, b ranges from 0-3, and c ranges from 0-3.

Abstract: A photonic Mach Zehnder Interferometer (MZI) has a first arm with a first photonic waveguide transmitting a first light having a first phase, a second arm with a second photonic waveguide transmitting a second light having a second phase, and a Transparent Conducting Oxide (TCO) based assembly. The TCO assembly is positioned about the first photonic waveguide of the first arm to modulate the first phase of the first light traveling in the first photonic waveguide.

Abstract: Due to the precautions put in place during the COVID-19 pandemic, utilization of telemedicine has increased quickly for patient care and clinical trials. Unfortunately, teleconsultation is closer to a video conference than a medical consultation with the current solutions setting the patient and doctor into a discussion that relies entirely on a two-dimensional view of each other. A telehealth platform is augmented by a digital twin of the patient that assists with diagnostic testing of ocular manifestations of myasthenia gravis. A hybrid algorithm combines deep learning with computer vision to give quantitative metrics of ptosis and ocular muscle fatigue leading to eyelid droop and diplopia. The system works both on a fixed image and video in real time allowing capture of the dynamic muscular weakness during the examination.

Abstract: The present disclosure provides method of treating or preventing a microbial infection caused by a prokaryotic pathogen in a subject, the method comprising administering a compound of Formula (I) as set forth in the specification. In one embodiment, the prokaryotic pathogen belongs to the genus Staphylococcus.

Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

Abstract: Systems and methods for microscopic imaging include an inverted microscope directed at a sample on a coverglass, where the sample is comprised of one or more cells and one or more chromophores. A ridge separates the coverglass from a silicon dioxide layer, and a silicon mirror is situated on the silicon dioxide layer, opposite the ridge and coverglass, while a weight is situated against the silicon mirror, opposite the silicon dioxide layer. The inverted microscope uses a spatial light modulator to diffract light through a linear polarizer and a filter wheel comprised of one or more Fourier filters. A beam or beams of s-polarized light is directed to the silicon mirror to create axial light modulation with its reflection on the silicon mirror, producing image data that is captured at a light detector.

Abstract: The present invention discloses a unique panel of gene transcripts down-regulated in patients with coronary artery disease (CAD). Methods and compositions for detecting CAD in patient blood samples are provided.

Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.

Abstract: The present disclosure relates to a process for preparing long-chain alkanes and alkenes from alcohols, aldehydes, or both. The process proceeds via acceptorless dehydrogenation and decarbonylative coupling using a supported catalyst.

Abstract: Systems and methods are disclosed for a centrosymmetric convolutional neural network (CSCNN), an algorithm/hardware co-design framework for CNN compression and acceleration that mitigates the effects of computational irregularity and effectively exploits computational reuse and sparsity for increased performance and energy efficiency.