Abstract: Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.
Type:
Application
Filed:
November 30, 2007
Publication date:
August 26, 2010
Applicants:
Georgetown University Medical School, MedStar Research Institute, Inc.
Inventors:
Anton Wellstein, Marcel O. Schmidt, Stephan Zbinden, Stephen Epstein, Mary Susan Burnett
Abstract: Methods for lipomodeling by peripherally administering a modulator of a Y receptor are provided. Methods may comprise reduction of a fat depot by administering a Y receptor antagonist proximally and/or directly to the site of the fat depot. Other methods comprise increasing or stabilizing a fat depot or fat graft by administering a Y receptor agonist proximally and/or directly to the site of the fat depot or fat graft. Also provided are methods for stimulating wound healing by administering a Y receptor agonist proximally to a wound site.
Type:
Application
Filed:
June 6, 2006
Publication date:
December 24, 2009
Applicant:
Georgetown University MEDICAL SCHOOL
Inventors:
Zofia Zukowska, Lydia Kuo, Stephen Baker, Michael Johnson, Edward W. Lee