Abstract: Compounds of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R.sub.1 and R.sub.2 together is a multifunctional carboxylic acid residue which forms a ring with the platinum atom through two oxygens of said multifunctional carboxylic acid; R.sub.3 is a deoxy mono or disaccharide or a derivative thereof; and R.sub.4 is selected from the group consisting of hydrogen, C.sub.1-4 -alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl, wherein substituents are selected from the group consisting of halogen, nitro, C.sub.1-2 -alkoxy, carboxy, carbony ester or phenyl or a pharmaceutically acceptable salt thereof are disclosed. Compositions containing these compounds and methods using these compounds are also discussed.

Abstract: A composition made up of a liposome-encapsulated vinca alkaloid is disclosed. This composition possesses an increased antitumor activity and a substantially lower toxicity as compared to free drug.

Abstract: Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having the formula ##STR1## wherein n is 0 or 1 and when n is 1 R.sub.1 is H or C.sub.1 -C.sub.4 alkyl, R is non-substituted higher alkyl or mono or disaccharide or a derivative of a mono or disaccharide,when n is O, R.sub.1 is H or C.sub.1 -C.sub.4 alkyl, R is H, halogen, non-substituted C.sub.1 -.sub.20 alkyl, aryl, arlalkyloxy, mono or disaccharide, or a derivative of a mono or disaccharide,and R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, C.sub.1.sup.-4 alkyl or R.sub.2 and R.sub.3 or R.sub.2 and R.sub.3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R.sub.2 and R.sub.3 together form a fused or bicyclic ring with adjacent carbon atoms, or R.sub.2 and R.sub.3 together are a substituted or unsubstituted C.sub.1-5 alkylene group; with the proviso that R and R.sub.

Abstract: Platinum compounds of the formulae: ##STR1## are disclosed. Compositions containing these compounds and methods of using the same in the treatment of tumors are also discussed.

Abstract: Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. The compound have the formula: ##STR1## wherein n is 0 or 1, R.sub.1 is selected from the group consisting of hydrogen, a mono or disaccharide or a derivative thereof linked to the nitrogen atom by a --NHCO-amide moiety, an --NHCS-- thioamide moeity or a --CO-- carbonylmoiety, R' is selected from the group consisting of hydrogen and C.sub.1-4 alkyl, and R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, C.sub.1-4 alkyl or R.sub.2 and R.sub.3 or R.sub.2 and R.sub.3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R.sub.2 and R.sub.3 together form a fused or bicyclic ring with adjacent carbon atoms; with the proviso that R' and R.sub.1 cannot both be hydrogen when n=o,or a pharmaceutically acceptable salt thereof.

Abstract: A rechargeable electrochemical storage cell comprising a housing, in the interior of which is an anode and a cathode spaced from each other and both provided with a core of glassy carbon, graphite or carbon cloth and both anode and cathode having thereon an electrodeposited coating of poly(2,6-naphthoquinone), said anode and cathode having therebetween an electrolyte of a buffer at a pH in the range of about 6 to 9.

Abstract: Stable, thermally reversible gels of organic solvents and a gelling agent having the formulaR.sub.1 --(CH.sub.2).sub.n --CO.sub.2 --R.sub.2wherein R.sub.1 is an anthracene analogue or substituted anthracene analogue, n is zero or a whole number from 2 to 20, and R.sub.2 is cholesteryl and cholestanyl or a derivative of cholesteryl or cholestanyl, processes for producing same, and novel anthracene analogue cholesteryl and cholestanyl esters and derivatives.

Abstract: This invention provides for a cephalosporin immobilized on a solid phase support comprising a beta-lactamase releasable, detectably labeled substituent at the 3-position thereof.This invention also provides for an assay for detecting the presence of beta-lactamase enzyme in a sample comprising:(a) immobilizing a cephalosporin on a solid phase support wherein at the 3-position of said cephalosporin is a detectably labeled substituent releasable by beta-lactamase;(b) contacting said sample with the immobilized cephalosporin of step (a); and,(c) detecting the released substituent.

Abstract: This invention discloses 1a- and 7-substituted derivatives of mitosanes containing thiocarbamoyl and glycosyl residues. The compounds possess antibacterial and antitumor activity, with a concomitant reduction in bone marrow toxicity as compared to the parent compounds.

Abstract: A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which entails injecting an effective amount of a 2-, 5- or 6-iodo-substituted hexose, as a contrast medium, into the mammalian body, and scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the central nervous system component or components.

Abstract: A method for detecting an antigen in a plasma or serum sample, which comprises conditioning the sample, wherein conditioning comprises either diluting the sample by a factor of at least 100 or dissociating the antigen in the sample from binding proteins with acid, base, or a chaotropic agent; drying the conditioned sampled; and detecting the antigen in the dried sample using an immunological assay is disclosed. The method is particularly useful for the detection of antigens associated with breast cancer.

Abstract: Compounds of the formula ##STR1## wherein X is halogen; each R independently represents H, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.4 alkanoyl group, a phosphate group, or a sulfate, sulfonate, or benzoate group with the proviso that no more than one sulfate, sulfonate, or benzoate group is present in said compound; and R' represents R or a carbohydrate residue derived from a carbohydrate having the formula R'OH with the proviso that R' and the R on C-2 or both R groups on C-3 and C-4 together can represent an isopropylidene group; or a pharmaceutically acceptable salt thereof, are disclosed along with methods of synthesizing and using these compounds.

Abstract: A process for removing immunosuppressive substances from the blood serum of cancer patients comprises contacting the serum at a temperature below room temperature and preferably not greater than 5.degree. C., with Protein A of S. aureus immobilized on a substrate. Conducting the immunoabsorption at low temperature reduces the amount of anaphylatoxins produced in the process and thereby reduces the side effects of immunoperfusion treatment. An apparatus for low-temperature immunoperfusion treatment comprises a chamber for containing the immunoabsorbent, inlet and outlet tubes connected to the chamber, and a cooling jacket surrounding the chamber and at least a portion of the inlet tube.

Abstract: Pictorial images of selected volume elements of materials are generated by a contactless, non-destructive, substantially hazard free tomographic technique in which the material is brought within the influence of a relatively low-strength electromagnetic field and subjected to plural preselected frequencies to provide output data which is used to generate an image reflective of the magnetic and/or electric and/or conductance properties of the selected volume elements. This data has a high volume information content which enables accurate and reproducible identification of the material under investigation. The technique has application in the medical diagnostic field such as for example in aiding in the detection of small areas of cancerous tissue present in a larger mass of healthy tissue.

Abstract: A rare earth/chelating agent complex is employed in digital fluoroscopy. More specifically, a contrast medium is utilized in digital fluoroscopy, the contrast medium consisting of a non-radioactive composition of a rare earth metal and a chelating agent. The rare earth metal is lutecium or ytterbium, while the chelating agent is DTPA, EHPG or HBED. The digital fluoroscopy method results in the development of diagnostic energy difference image information as a result of application of X-ray beams of two different energy levels, coupled with subtraction processing of the resulting image information.

Abstract: A computerized electro-oculographic (CEOG) system with feedback control of test stimuli comprises an integrated system for automated administration of electro-oculographic tests and visual evoked response tests to a patient, automated processing of the results derived from such tests, and automated feedback control of the test stimuli in accordance with the processed test results. The CEOG system is responsive to operator selection of desired stimuli to be administered, as well as to operator specification of various test stimuli characteristics, for automatically administering to the patient the test stimuli having the desired characteristics. Electrode test data derived therefrom are immediately recorded on-line, and are immediately and automatically analyzed to provide critical information for immediate display in acceptable format and in a very short period of time.

Abstract: Radioactive staining of gels is employed to identify proteins. A radioactive stain composition is formed by introducing radioactive iron isotope into ferrous bathophenanthroline sulfonate by adding crystalline ascorbic acid and acetic acid to a .sup.59 FeCl.sub.3 solution, adding aqueous BPS solution after the dissolution of the crystals, and adding methanol and acetic acid to yield the radioactive stain composition. Alternatively, the radioactive stain composition may be formed by bombarding a non-radioactive stain with thermal neutrons. The method of identifying proteins with the radioactive stain composition basically comprises the steps of placing the protein in the gel, forming a radioactic stain composition, and applying the radioactivated stain composition to the gel. To demonstrate the protein present, either a gamma scintillation counting technique or radioautography is preferably employed.

Abstract: A digital fluorographic method and system calls for digitizing and storing first and second x-ray picture information derived prior to and after, respectively, injection of a contrast medium into the subject. The first and second x-ray picture information are digitized, stored and processed to develop first and second processed picture data, respectively, and the first and second processed picture data are subtractively combined to produce picture data corresponding to a pictorial representation of differences between the x-ray picture information prior to and after, respectively, the injection of the contrast medium.

Abstract: The non-linear conductance and capacitance characteristics of electrically non-homogenous materials over a given frequency range are used to identify and analyze such materials.

Abstract: Anthracycline glycoside antibiotics are complexed with cardiolipin and then encapsulated in liposomes to reduce mammalian cardiac tissue uptake of the anthracycline glycoside and to thereby reduce the deleterious effect of such cardiac tissue uptake. The invention is directed to the composition, preparation and use of the encapsulated complex of anthracycline glycoside.