Abstract: Recombinant viral vectors are disclosed that contain a nucleic acid encoding a Second Mitochondria-derived Activator of Caspases (Smac) protein inserted within an RNA virus genome, wherein the Smac protein specifically binds to at least a portion of an Inhibitor of Apoptosis Protein (IAP). Also disclosed are methods of treating cancer using the disclosed vectors.

Abstract: Disclosed herein are composite materials and methods of making and use thereof. The composite materials comprise: a carbon nanotube and a plurality of ferrihydrite particles disposed on the carbon nanotube, the composite material comprising the plurality of ferrihydrite particles and the carbon nanotube in a weight ratio of from 5:95 to 95:5. The weight ratio can be selected such that the composite material has a desired balance between specific surface area and specific capacitance. Also disclosed herein are methods comprising: making a plurality of the composite materials, the weight ratio of the plurality of ferrihydrite particles and the carbon nanotube being different for each composite material; and determining and comparing the specific surface area and specific surface capacitance for the plurality of composite materials to determine the weight ratio at which the composite material has a desired balance between the specific surface area and the specific capacitance.

Abstract: The present invention provides methods for detecting and/or treating a subject having an aneurysm or at risk for developing an aneurysm. It has been discovered that a key metabolite of the kynurenine (Kyn) pathway, a major route for the metabolism of essential amino acid tryptophan (Trp) into nicotinamide adenine dinucleotide (NAD+), plays a critical role in the formation of aneurysms, for example abdominal aortic aneurysms. In particular, it has been discovered that 3-Hydroxyanthranilic acid (3-HAA), a product of kynureninase (KYNU), plays a causative role in the formation of aneurysms by, for example exerting pro-inflammatory effects on vascular smooth muscle cells. It has further been discovered that elevated levels of 3-HAA are indicative of the presence and/or progression of an aneurysm, and 3-HAA levels correlate with the size (aortic diameter) of the aneurysm.

Abstract: A deep learning based method for integrating demand forecasting and scheduling of online ride-hailing at a hub is provided. The method includes: S1, performing data processing: performing missing value filling, outlier processing and normalization processing on the historical orders of online ride-hailing and relevant feature data of the urban transportation hub; S2, performing feature screening: primarily screening the relevant features by means of a Pearson correlation test and box plot analysis, calculating an influence degree of data of each feature on the orders of online ride-hailing by using an XGBoost algorithm, and secondarily screening the features; S3, performing model construction: constructing an integrated model for demand forecasting and scheduling decision of online ride-hailing at the urban transportation hub; and S4: performing algorithm design: designing a decision tree and deep learning combination algorithm, and calculating the number of online hailed rides to be scheduled.

Abstract: Embodiments of the present invention relate generally the use of compositions comprising a glutathione precursor and a selenium source, e.g., compositions which elevate intracellular glutathione, in the prevention and treatment of Zika viral diseases, e.g., Zika fever. Related embodiments are directed to use of such compositions, e.g., compositions comprising a glutathione precursor and a selenium source, in reducing the infectivity of Zika viruses or Zika viral particles.

Abstract: Novel rhodanine derivatives and methods for their use are provided herein. The rhodanine derivatives are useful in treating or preventing viral infections, including coronavirus infections (e.g., a SARS-CoV-2 virus infection). The rhodanine derivatives are also useful as photosensitizers for photodynamic therapy in treating or preventing cancer in a subject.

Abstract: Described herein are technologies for concentrating rare-earth elements from a heavy fraction of grit in gangue produced in kaolin mining. In some examples, grit is separated as a non-clay fraction of gangue produced in a kaolin mining operation. The grit is separated into a heavy mineral grit sub-fraction and a light mineral grit sub-fraction. Rare-earth elements, particularly heavy rare-earth elements, are thereafter extracted from the heavy mineral grit sub-fraction using various extraction technologies.

Abstract: Embodiments of the present systems and methods may provide improved capability to predict the risk of recurrence of ductal carcinoma in situ (DCIS) conditions using whole slide image analysis based on machine learning techniques. For example, in an embodiment, a computer-implemented method for determining treatment of a patient may comprise receiving an image of living tissue of a patient, annotating the entire image into tissue structures, extracting texture features from the annotated image, determining a distribution of the extracted texture features relative to tissue conditions, classifying the patient into a risk group based on the distribution, and treating the patient accordingly based on the risk group.

Abstract: The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.

Abstract: The present disclosure is concerned with compounds, compositions, and methods for synthesizing sphingosines and glycolipids including glycosphingolipids, such as but not limited to lactosyl sphingosine.

Abstract: The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.

Abstract: Compositions and methods of making a culture medium from a polymeric material are described herein. The method can include (a) depolymerizing and/or dispersing the polymeric material to obtain a depolymerized and/or dispersed residue, and (b) combining the depolymerized and/or dispersed residue with one or more adjuvants to form a culture medium. In some embodiments, the polymeric material can be a plastic article, such as a waste carpet material. Culture media prepared from the compositions and methods are also described. The culture media are suitable for culturing microorganisms including bacterium, algae, and fungus. The microorganisms can be used to produce a bioproduct such as a biopolymer, an enzyme, or a cellular metabolite.

Abstract: Disclosed herein are compounds having antiviral activity, and, in particular, an inhibitory activity on the replication of Respiratory Syncytial Virus (RSV). Druggable target sites, including Px, in the RSV N protein are disclosed, as well as compounds targeting Px. The compounds can be used to treat patients with RSV infection.

Abstract: Provided herein are DNA-glycan conjugates that include a glycan and a covalently attached polynucleotide. The polynucleotide includes a plurality of modules. Each module includes a nucleotide string, and the plurality of modules includes a monomer module that corresponds to each carbohydrate monomer present in the DNA-glycan conjugate, and a linkage module that corresponds to each glycosidic linkage present between each carbohydrate monomer in the DNA-glycan conjugate. The nucleotide sequence of the plurality of modules corresponds to the glycan structure. Also provided herein are methods for making and using the DNA-glycan conjugates. Further provided is a computer-implemented method for translating data from a nucleotide sequence to a glycan structure, a system for converting data from a glycan structure to a nucleotide sequence, and a system for translating data from a nucleotide sequence to a glycan structure.

Abstract: The compositions and methods are described for generating an immune response to a hepatitis B virus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a hepatitis B virus, in the subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat an infection caused by hepatitis B virus.

Abstract: Embodiments of the present disclosure provide for contrast agents, methods of making contrast agents, and methods of using contrast agents, and the like.

Abstract: Disclosed are compositions comprising Rhamnus prinoides (GESHO) extract or fragments thereof and methods of using Gesho extract for the inhibition of biofilm formation.

Abstract: The present invention provides processes for the synthesis of organic azides, intermediates for the production thereof, and compositions related thereto.

Abstract: The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs.

Abstract: Compounds and methods for use to treat a bacterial infection caused by, for example, gram positive bacteria, gram negative bacteria, and/or mycobacteria are provided herein. Also provided herein are compounds and methods for use in potentiating the effect of an antibiotic in the treatment of a bacterial infection. Pharmaceutical compositions including the compounds as described herein are also provided.