Patents Assigned to Georgia State University Foundation, Inc.
-
Patent number: 8303946Abstract: The present invention is directed to methods and compositions that are effective in the inhibition of viral replication. In particular, the methods and compositions are effective at interfering with the activity of host cell proteins required in viral replication. For example, an embodiment of the invention is directed to inhibition of flavivirus replication wherein the replication is effected by changing the normal interactions of the host cell protein TIAR or TIA-1.Type: GrantFiled: September 2, 2003Date of Patent: November 6, 2012Assignee: Georgia State University Foundation, Inc.Inventors: Margo A. Brinton, Wei Li
-
Patent number: 5304647Abstract: A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof.The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product.Type: GrantFiled: August 24, 1990Date of Patent: April 19, 1994Assignee: Georgia State University Foundation, Inc.Inventors: Lucjan Strekowski, Maria Mokrosz, Donald B. Harden
-
Patent number: 5281616Abstract: Compositions for the inhibition of replication of human immunodeficiency virus containing one or more "porphyrins" possessing antiviral activity. As used herein "porphyrins" includes porphyrins, phthalocyanines, chlorins, metallo derivatives thereof, and other porphyrin-like compounds. Examples of natural and synthetic, positively, negatively, and neutrally charged porphyrins, phthalocyanines, and derivatives thereof have been found to exhibit selective anti-HIV activity which is not dependent on the presence of light.Type: GrantFiled: April 24, 1992Date of Patent: January 25, 1994Assignees: Georgia State University Foundation, Inc., Emory UniversityInventors: Dabney W. Dixon, Raymond F. Schinazi, Luigi G. Marzilli
-
Patent number: 5192788Abstract: Compositions for the treatment or prevention of AIDS or other diseases resulting from infection with the Human Immunodeficiency Virus containing one or more porphyrins.Porphyrins are tetrapyrrole macrocyle compounds with bridges of one carbon joining the pyrroles. Porphyrins occur naturally and are made synthetically. Derivatives of porphyrins include porphyrins with one or more substituents on one or more of the rings, porphyrins in which the conjugation of the ring has been altered by addition of substituents, porphyrins in which one or more center nitrogens is attached to substituents such as metals, liganded metals, and organic moieties, metalloporphyrins and metalloporphyrin-ligand complexes.Examples of natural and synthetic, positively, negatively, and neutrally charged porphyrins and porphyrin derivatives have been found to exhibit selective anti-HIV activity which is not dependent on the presence of light.Type: GrantFiled: May 23, 1988Date of Patent: March 9, 1993Assignees: Georgia State University Foundation, Inc., Emory UniversityInventors: Dabney W. Dixon, Raymond F. Schinazi, Luigi G. Marzilli
-
Patent number: 5109016Abstract: Compositions for the inhibition of replication of human immunodeficiency virus containing one or more "porphyrins" possessing antiviral activity. As used herein "porphyrins" includes porphyrins, phthalocyanines, chlorins, metallo derivatives thereof, and other porphyrin-like compounds. Examples of natural and synthetic, positively, negatively, and neutrally charged porphyrins, phthalocyanines, and derivatives thereof have been found to exhibit selective anti-HIV activity which is not dependent on the presence of light.Type: GrantFiled: May 22, 1989Date of Patent: April 28, 1992Assignees: Georgia State University Foundation, Inc., Emory UniversityInventors: Dabney W. Dixon, Raymond F. Schinazi, Luigi G. Marzilli
-
Patent number: 4963676Abstract: A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof.The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product.Type: GrantFiled: August 30, 1989Date of Patent: October 16, 1990Assignee: Georgia State University Foundation, Inc.Inventors: Lucjan Strekowski, Maria Mokrosz, Donald B. Harden
-
Patent number: 4929726Abstract: A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof.The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product.Type: GrantFiled: February 9, 1988Date of Patent: May 29, 1990Assignee: Georgia State University Foundation, Inc.Inventors: Lucjan Strekowski, Maria Mokrosz, Donald B. Harden