Patents Assigned to Gerbu Biotechnik GmbH
  • Method for increasing the yield of antibodies in the techniques of immunology
    Patent number: 6083513
    Abstract: The improved method uses N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) or N-acetylglucosaminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) in low dose ranges in a combination with zinc-L-proline complex and with immunostimulating lipid in doses which synergistically potentiate the effect of each single component whereby the zinc-L-proline complex contains an excess of L-proline or 5-oxo-L-proline which serves as a solubilizer and dispersing agent for the lipid component.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: July 4, 2000
    Assignee: GERBU Biotechnik GmbH
    Inventor: Nikolaus Grubhofer
  • Method for increasing the yield of antibodies in the techniques of immunology
    Patent number: 6004564
    Abstract: The new method uses synthetic glycopeptides such as MDP and GMDP as immunological adjuvants which according to this invention are added to the antigen in purely aqueous solution in the low doses discovered to evoke the maximum production of antibody output and whereby the adjuvant is present in dry form with L-proline added for better reproducibility of experiments by minimizing adsorptive losses at the walls of the glass vials.
    Type: Grant
    Filed: October 13, 1995
    Date of Patent: December 21, 1999
    Assignee: Gerbu Biotechnik GmbH
    Inventor: Nikolaus Grubhofer
  • Method for improving the yield of immunoantibodies in the vaccination of animals and humans
    Patent number: 5919466
    Abstract: Immunological adjuvant containing GMDP (N-acetyl-glucos-aminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine) and a colloidal, ultrafiltrable solution of solid, biodegradable lipids suitable as an additive in veterinary and human vaccines.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: July 6, 1999
    Assignee: GERBU Biotechnik GmbH
    Inventor: Nikolaus Grubhofer
  • Method of preparing a synergistic immunological adjuvant formulation
    Patent number: 5773011
    Abstract: The improved method uses N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) or N-acetylglucosaminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) in low dose ranges in a combination with zinc-L-proline complex and with immunostimulating lipid in doses which synergistically potentiate the effect of each single component whereby the zinc-L-proline complex contains an excess of L-proline or 5-oxo-L-proline which serves as a solubiliser and dispersing agent for the lipid component.
    Type: Grant
    Filed: July 21, 1995
    Date of Patent: June 30, 1998
    Assignee: Gerbu Biotechnik GmbH
    Inventor: Nikolaus Grubhofer