Patents Assigned to Geymonat S.p.A.
  • PlGF-1 in homodimeric form
    Patent number: 8962555
    Abstract: The present invention relates to a new homodimeric form of recombinant PlGF-1, to a process for its preparation and to compositions containing it.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: February 24, 2015
    Assignees: Dompe S.p.A., Geymonat S.p.A.
    Inventors: Gaetano D'Anniballe, Franck Martin, Giuseppe Salvia
  • Muteins of placental growth factor type I, preparation method and application thereof
    Patent number: 7807178
    Abstract: The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing the derivatives. The invention likewise relates to the production of antibodies for the derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.
    Type: Grant
    Filed: December 31, 2007
    Date of Patent: October 5, 2010
    Assignee: Geymonat S.p.A.
    Inventor: Giuseppe Salvia
  • Production process of recombinant placental growth factor
    Patent number: 7744862
    Abstract: Process for extracting and purifying the recombinant Placental Growth Factor (PLGF) expressed in inducible prokaryotic expression systems comprising the following steps: I) fermentation of the bacterial cells, II) extraction and purification of the inclusion bodies, III) renaturation of the expressed protein, IV) ion-exchange chromatography, V) reverse-phase chromatography.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: June 29, 2010
    Assignee: Geymonat S.p.A.
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci
  • Pharmaceutical and cosmetic compositions comprising plgf-1
    Patent number: 7364722
    Abstract: The invention relates to the preparation of placental growth factor (PLGF)-comprising therapeutic and cosmetic compositions capable of increasing angiogenesis of the cutaneous, subcutaneous and internal organ connective tissue. Such compositions are suitable for the treatment of pathological or natural states benefiting from the formation or regeneration of new vessels of the cutaneous compartment, such as scleroderma, its various manifestations, skin aging or loss of hair.
    Type: Grant
    Filed: March 5, 2003
    Date of Patent: April 29, 2008
    Assignee: Geymonat S.p.A.
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci
  • Pharmaceutical and Cosmetic Compositions Comprising PLGF-1
    Publication number: 20050239698
    Abstract: Abstract of the Disclosure The invention relates to the preparation of placental growth factor (PLGF)-comprising therapeutic and cosmetic compositions capable of increasing angiogenesis of the cutaneous, subcutaneous and internal organ connective tissue. Such compositions are suitable for the treatment of pathological or natural states benefiting from the formation or regeneration of new vessels of the cutaneous compartment, such as seleroderma, its various manifestations, skin ageing or loss of hair.
    Type: Application
    Filed: November 22, 2004
    Publication date: October 27, 2005
    Applicant: Geymonat S.p.A.
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci
  • Muteins of placental growth factor type 1, preparation method and application thereof
    Publication number: 20050176634
    Abstract: The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.
    Type: Application
    Filed: May 19, 2003
    Publication date: August 11, 2005
    Applicant: GEYMONAT S.p.A.
    Inventors: Domenico Maglione, Mauro Battisti, Ettore Conti, Giuseppe Salvia, Marina Tucci, Alberto Mion