Patents Assigned to GFLAS LIFE SCIENCES, INC.
  • Sequence-specific in vivo cell targeting
    Patent number: 11491208
    Abstract: Enhanced, specific nucleic acid targeting complexes comprising endo and exonuclease activity, and related methods that allow both targeted degradation of specific and/or non-specific nucleic acids in vivo and specific temporal regulation of nuclease activity to prevent off-target activity are disclosed herein. Through practice of the disclosure, nucleic acids, and cells harboring them, such as cancer cells or pathogens, are selectively degraded in vivo.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: November 8, 2022
    Assignees: GFLAS LIFE SCIENCES, INC., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Sungyong In, Sunghwa Choe, Mi Jin Park, Aiden Y. Park, Jung Hak Lim, Dong Wook Kim, Youngdong Yoo, Jongjin Park
  • Compositions and methods for genome engineering with Cas12a proteins
    Patent number: 11434478
    Abstract: The present disclosure provides novel Cas12a proteins, which cleave target nucleic acids and methods of use thereof.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: September 6, 2022
    Assignees: GFLAS LIFE SCIENCES, INC., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Sunghwa Choe, Jongjin Park, Ji Young Yoon, Han Seong Kim, Dong Wook Kim
  • Chimeric genome engineering molecules and methods
    Patent number: 11293019
    Abstract: The present disclosure provides compositions and methods for increasing mutation efficiency and homologous recombination rates of site-specific endonucleases. The compositions and methods comprise a chimeric polypeptide comprising a site-specific endonuclease or a domain thereof and a functional moiety. The current inventions relate to functional enhancement of the CRISPR-Cas enzymes. Disclosed herein include possible variants and their intended improvements.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: April 5, 2022
    Assignees: GFLAS LIFE SCIENCES, INC., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Jongjin Park, Ji Young Yoon, Sunmee Choi, Mijin Park, Slki Park, Aiden Y. Park, Jung Hyuk Lee, Junghak Lim, Dong Wook Kim, Sunghwa Choe