Abstract: A method to reduce or ameliorate an ocular condition, such as ocular scarring that may occur after ocular surgery or another non-surgical ocular inflammatory or other condition, by topically administering doxycycline as the sole active agent to a patient in need thereof under conditions to reduce or ameliorate the ocular condition.

Abstract: A method and composition for hyperthermally treating cells in the eye with simultaneous imaging. The heat (temperature) production inside the eye ( target) tissue is imaged. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturation. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 50° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

Abstract: A method for dissemination of a biocompatible agent using a neural conduit. In one embodiment, agent dissemination is facilitated, for example, by the application of thermal energy, ultrasound energy, radiant energy, electromagnetic energy, or electrical current. As one example, agent may be provided to a sensory organ such as the eye, ear, or nose, for dissemination along the optic nerve to the central nervous system. As another example, agent may be provided at an acupuncture site for dissemination along a peripheral nerve to either a second peripheral nerve site or a central nervous system site.

Abstract: A radiopaque liquid to protect normal tissue from radiation induced damage. A radiopaque liquid such as a fluorocarbon is introduced into a body cavity to protect tissues adjacent to a target radiation site. The radiopaque liquid prevents radiation penetration into protected cavities. In one embodiment, perfluorooctylbromide is used as the radiopaque liquid to replace vitreous gel in irradiating an intraocular tumor.

Abstract: A method for detecting blood flow in the retina and choroid uses a scanning laser ophthalmoscope and a lipophilic fluorescent dye contained in carrier. The fluorescent dye in one embodiment is able to fluoresce in the visible and near infrared spectral range. The carrier can alternatively contain dye that fluoresces in the visible range and a dye that fluoresces in the infrared spectral range. The fluorescent dye enables the carrier to be visualized in the retina and the choroid.

Abstract: A system for detecting blood flow in blood vessels uses a scanning laser fundus camera and a fluorescent dye-containing carrier such as microcapsules or vesicles. The vesicles may be liposomes or blood cells. The fluorescent dye is contained within the carrier at a concentration to fluoresce when subjected to the laser beam. The carrier may be submicron in size and preferably about 0.02 to 2.0 microns. The fluorescent dye enables the carrier to be visualized by the fundus camera. The fundus camera records the image of the fluorescing carrier in the blood vessel and converts the image to a video signal for viewing or storage.