Patents Assigned to GIGAGEN
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Publication number: 20230265192Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to CTLA-4 and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.Type: ApplicationFiled: July 2, 2021Publication date: August 24, 2023Applicant: GigaGen, Inc.Inventors: David Scott JOHNSON, Adam Shultz ADLER, Rena Aviva MIZRAHI, Yoong Wearn LIM, Michael ASENSIO, Erica Lyn STONE
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Patent number: 11718660Abstract: Provided herein are compositions comprising recombinant polyclonal protein (RPP) derived from mammalian plasma cells and plasmablasts. Specifically, RPPs specific to Zika virus are provided. Also provided are the methods of using the RPP for treatment of viral infection and the methods of making the RPPs.Type: GrantFiled: September 8, 2021Date of Patent: August 8, 2023Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Sheila Keating, Adam Shultz Adler, Michael Asensio, Kacy Stadtmiller, Emily Benzie, Ariel Niedecken, Angelica V. Medina-Cucurella, Rena Aviva Mizrahi, Yoong Wearn Lim
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Patent number: 11702765Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.Type: GrantFiled: May 28, 2020Date of Patent: July 18, 2023Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
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Patent number: 11685779Abstract: Provided herein are compositions comprising recombinant polyclonal proteins (RPPs) derived from mammalian plasma cells and plasmablasts. Also provided are methods of using the RPPs.Type: GrantFiled: July 27, 2021Date of Patent: June 27, 2023Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Sheila Keating, Adam Shultz Adler, Michael Asensio, Kacy Stadtmiller, Emily Benzie, Ariel Niedecken, Angelica V. Medina-Cucurella, Rena Aviva Mizrahi, Yoong Wearn Lim
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Patent number: 11591652Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.Type: GrantFiled: November 8, 2021Date of Patent: February 28, 2023Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Everett Hurteau Meyer
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Patent number: 11441240Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.Type: GrantFiled: May 16, 2019Date of Patent: September 13, 2022Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Shultz Adler, Matthew James Spindler, Rena Aviva Mizrahi
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Patent number: 11427933Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.Type: GrantFiled: August 3, 2021Date of Patent: August 30, 2022Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Shultz Adler, Matthew James Spindler, Rena Aviva Mizrahi
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Patent number: 11111490Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.Type: GrantFiled: June 17, 2019Date of Patent: September 7, 2021Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Shultz Adler, Matthew James Spindler, Rena Aviva Mizrahi
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Patent number: 11053543Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.Type: GrantFiled: May 27, 2020Date of Patent: July 6, 2021Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Everett Hurteau Meyer
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Patent number: 10787706Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.Type: GrantFiled: October 3, 2019Date of Patent: September 29, 2020Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Everett Hurteau Meyer
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Patent number: 10689641Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.Type: GrantFiled: April 30, 2019Date of Patent: June 23, 2020Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
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Patent number: 10465243Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.Type: GrantFiled: September 14, 2018Date of Patent: November 5, 2019Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Everett Hurteau Meyer
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Patent number: 10329557Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.Type: GrantFiled: March 13, 2018Date of Patent: June 25, 2019Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Shultz Adler, Matthew James Spindler, Rena Aviva Mizrahi
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Patent number: 10214740Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.Type: GrantFiled: May 16, 2016Date of Patent: February 26, 2019Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
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Patent number: 10106789Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.Type: GrantFiled: February 13, 2017Date of Patent: October 23, 2018Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Everett Hurteau Meyer
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Patent number: 9738699Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.Type: GrantFiled: May 19, 2016Date of Patent: August 22, 2017Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
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Patent number: 9695474Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.Type: GrantFiled: May 19, 2016Date of Patent: July 4, 2017Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Everett Hurteau Meyer
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Patent number: 9422547Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.Type: GrantFiled: June 9, 2015Date of Patent: August 23, 2016Assignee: GigaGen, Inc.Inventors: David Scott Johnson, Adam Adler, Rena Mizrahi
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Publication number: 20150154352Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsions or droplets. A biological sample is divided into subsamples of single cells or cell supbopulations, and a fusion complex is formed by molecular linkage and amplification techniques. Methods, apparatuses, and systems are provided for high-throughput, massively parallel analysis of the subsamples. These methods integrate molecular, algorithmic, and engineering approaches. They have broad and useful application in a number of biological and medical fields, including immunology, noninvasive prenatal diagnosis, and noninvasive cancer diagnosis.Type: ApplicationFiled: June 21, 2013Publication date: June 4, 2015Applicant: GigaGen, Inc.Inventors: David Scott Johnson, Andrea Loehr, Thomas Hunt, Everett Hurteau Meyer, Walter Mathias Howell, Gary Withey
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Publication number: 20140057799Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.Type: ApplicationFiled: December 16, 2011Publication date: February 27, 2014Applicant: GIGAGENInventors: David Scott Johnson, Everett Hurteau Meyer