Patents Assigned to Gipharmex, S.p.A.
  • Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
    Patent number: 4981983
    Abstract: New derivatives of chenodeoxycholic, ursodeoxy cholic, cholic and ursocholic acids, bearing a methyl group in the side chain in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described.The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: January 1, 1991
    Assignee: Gipharmex S.p.A.
    Inventors: Virginio Castagnola, E. Giuliano Frigerio, Roberto Pellicciari, Aldo Roda
  • Complex of products for the rapid and not-invasive treatment of biliary calculosis
    Patent number: 4931038
    Abstract: The present invention relates to a complex of products useful for the not-invasive and rapid treatment of the biliary calculosis of cholesterolic nature. It is based upon the coupling of a special apparatus generating medium-energy or medium-low-energy ultrasounds with pharmaceutical compositions based on biliary acids, capable of de-saturating bile super-saturated with cholesterol.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: June 5, 1990
    Assignee: Gipharmex S.p.A.
    Inventors: Giuliano Frigerio, Aldo Roda, Enrico Roda
  • Biliary acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
    Patent number: 4921848
    Abstract: Compounds of formula I ##STR1## wherein: R.sub.1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in .alpha. or .beta. configuration, are useful in human therapy. Compounds I are prepared by methylation of the corresponding appropriately protected 7-keto-derivatives.
    Type: Grant
    Filed: October 19, 1988
    Date of Patent: May 1, 1990
    Assignee: Gipharmex S.P.A.
    Inventors: Giuliano Frigerio, Roberto Pellicciari, Aldo Roda
  • Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
    Patent number: 4892868
    Abstract: New derivatives of chenodeoxycholic, ursodeoxycholic, cholic and ursocholic acids, bearing a methyl group in the side chain, in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described.The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: January 9, 1990
    Assignee: Gipharmex, S.p.A.
    Inventors: Virginio Castagnola, E. Giuliano Frigerio, Roberto Pellicciari, Aldo Roda