Patents Assigned to Gist-Brocades N.V.
  • Patent number: 4515777
    Abstract: Vaccines derived from aviair reo-virus to combat aberations of the skeleton such as rachitis--like symptoms, diarrhoea and growth inhibition, a process for their preparation as well as combined, inactivated vaccines, ready for administration and active against at least Newcastle disease and aberations of the skeleton, diarrhoea and growth inhibition and process for the preparation of such vaccine.
    Type: Grant
    Filed: November 10, 1982
    Date of Patent: May 7, 1985
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: 4505892
    Abstract: Infectious bronchitis (IB) vaccines for poultry derived from at least one novel virus strain of novel infectious bronchitis serotypes, selected from the group consisting of culture Nos. CNCTC A 07/80, CNCTC A 08/80, CNCTC A 09/80, CNCTC A 010/80, CNCTC A 011/80, CNCTC A 013/80, CNCTC A 014/80, CNCTC A 015/80 and CNCTC A 016/80 deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague, Czechoslovakia and the novel viruses per se, combined virus vaccaines and a novel method of protecting poultry from infectious bronchitis.
    Type: Grant
    Filed: August 31, 1983
    Date of Patent: March 19, 1985
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: 4500638
    Abstract: Infectious bronchitis (IB) vaccines for poultry derived from at least one novel virus strain of novel infectious bronchitis serotypes, selected from the group consisting of culture Nos. CNCTC A 07/80, CNCTC A 08/80, CNCTC A 09/80, CNCTC A 010/80, CNCTC A 011/80, CNCTC A 013/80, CNCTC A 014/80, CNCTC A 015/80 and CNCTC A 016/80 deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague, Czechoslovakia and the novel viruses per se, combined virus vaccines and a novel method of protecting poultry from infectious bronchitis.
    Type: Grant
    Filed: October 29, 1982
    Date of Patent: February 19, 1985
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: 4496720
    Abstract: A novel process for the preparation of thioethers comprising reacting a silylated thiol of the formulaR--S--SiR.sub.1 R.sub.2 R.sub.3 Iwherein R is an organic group and R.sub.1, R.sub.2 and R.sub.3 are individually selected from the group consisting of alkyl of 1 to 4 carbon atoms with an organic halide, sulfate or sulfonate in the presence of hexamethylphosphoric triamide as a solvent or co-solvent preferably under neutral conditions in aprotic solvents at a temperature between 0.degree. and 150.degree. C.
    Type: Grant
    Filed: March 7, 1983
    Date of Patent: January 29, 1985
    Assignee: Gist-Brocades N.V.
    Inventors: Cornelis A. Bruynes, Theodorus K. Jurriens
  • Patent number: 4490258
    Abstract: An oxidative biological purification process for waste water in a fluidized-bed reactor at a pH between 5 and 8 in the oxidation space comprising passing waste water upwards through an air-sparged oxidation space containing aerobic biomass attached to insoluble carrier particles of a size of 0.1 to 2 mm with a specific gravity of 2 to 5 g/cm.sup.3 at such a rate that space loads of COD of 4-50 kg/m.sup.3 day are achieved while continuously and completely separating purified waste water leaving the oxidation space from said attached aerobic biomass, whereby the aerobic biomass prevails to at least a very substantial extent in a state of attachment to said carrier particles, undue surplus formation of said sludge being minimized by continuous control of the residence time of the waste water to be treated in the oxidation space between the limits of 0.3 to 20 hours, and at least all attached aerobic biomass is recycled to the oxidation space by way of settling.
    Type: Grant
    Filed: May 19, 1983
    Date of Patent: December 25, 1984
    Assignee: Gist-Brocades N.V.
    Inventors: Joseph J. Heijnen, Pieter A. Lourens, Cornelis P. Venema, Albert J. Vroemen
  • Patent number: 4481188
    Abstract: Infectious bronchitis vaccines for poultry derived from at least a virus strain of a novel serotype of the infectious-bronchitis virus (IBV), identified by the internal indication Gelderland. 901 and Brabant. 802, which have been deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology under the numbers CNCTC AO 17/81 and CNCTC AO 18/82 and at the Collection Nationale de Cultures de Microorganismes d'Institut Pasteur, under Nos. I-168 and I-202 and combined infectious-bronchitis vaccines derived from the IBV H. 120 or the IBV H. 52 of the Massachusetts type strain together with the novel before-mentioned virus strain; the infectious-bronchitis virus strain itself, and a process for preventing infectious-bronchitis in poultry by vaccination with a vaccine derived from the before-mentioned strains. Preferably, live infectious bronchitis vaccines are prepared, which contain a virus content of at least 10.sup.4..sup.0 EID.sub.
    Type: Grant
    Filed: August 20, 1982
    Date of Patent: November 6, 1984
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: 4476129
    Abstract: The invention relates to new piperazine derivatives of the general formula ##STR1## in which R' and R.sup.2 each represents 1, 2 or 3 halogen atoms, which may be the same or different,R.sup.3 represents a hydrogen atom or 1, 2 or 3 halogen atoms, X represents a hydroxy, C.sub.1-4 alkoxy, phenylcarbamoyloxy or C.sub.1-4 alkylcarbamoyloxy group,Y represents a hydrogen atom or a C.sub.1-3 alkyl group, or X and Y together with the carbon atom to which they are linked represent a carbonyl group,m is 1, 2 or 3,n is 0 or 1, with the proviso that m+n is at most 3, and their acid addition and quaternary ammonium salts.Other features of the invention areprocesses for the preparation of compounds of formula I,pharmaceutical preparations comprising a compound of formula I.
    Type: Grant
    Filed: June 29, 1983
    Date of Patent: October 9, 1984
    Assignee: Gist-Brocades N.V.
    Inventors: Johan Gootjes, Hendricus H. van de Kamp
  • Patent number: 4442091
    Abstract: The invention provides a method for combatting and/or preventing allergic diseases which are caused by house-dust mites by treating said mites or places or areas which are afflicted or may be afflicted by said mites with an effective amount of natamycin.
    Type: Grant
    Filed: April 29, 1982
    Date of Patent: April 10, 1984
    Assignee: Gist-Brocades N.V.
    Inventors: Philippe Lebrun, Daniele de Saint Georges-Gridelet
  • Patent number: 4422971
    Abstract: A novel process for the preparation of 6-aminopenicilanic acid-1,1-dioxide and its non-toxic, pharmaceutically acceptable salts by deacylation of a penicillin-1,1-dioxide or its salts of which the 3-carboxylic acid is protected by such an easily removable group that a "one-pot process" is possible.
    Type: Grant
    Filed: August 4, 1981
    Date of Patent: December 27, 1983
    Assignee: Gist-Brocades N.V.
    Inventors: Piet J. Akkerboom, Christophorus Oldenhof
  • Patent number: 4400472
    Abstract: A novel rabies virus strain No. 675 deposited in the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague under number CNCTO AO 4/77, novel living or inactivated cell culture vaccines derived therefrom, a process for the isolation of the virus strain as well as a process for the preparation of the said vaccines and novel method of immunizing warm-blooded animals against rabies.
    Type: Grant
    Filed: October 13, 1981
    Date of Patent: August 23, 1983
    Assignee: Gist-Brocades N.V.
    Inventor: Gosse Bijlenga
  • Patent number: 4400509
    Abstract: An improved process for the trimethylsilylation of organic compounds with at least one active hydrogen atom with hexamethyldisilazane, the improvement comprising effecting the reaction in the presence of 0.001 to 10 mole percent of a catalyst of the formulaX--NH--Y Iwherein X and Y are individually an electron-withdrawing group or when X is an electron-withdrawing group, Y is selected from the group consisting of hydrogen and trialkylsilyl of 1 to 6 carbon atoms or X and Y together with the nitrogen atom to which they are attached form a cyclic electron-withdrawing group and novel trimethylsilylated thiols of the formula ##STR1## wherein R is a 5-or 6-membered heterocycle having at least one nitrogen or sulfur heteroatom and optionally substituted with at least one member of the group consisting of alkyl of 1 to 6 carbon atoms, phenyl, trimethylsilyl, trimethylsilyloxycarbonylmethyl and alkylamino of 1 to 6 carbon atoms, and novel trimethylsilylated 3'-substituted cephalosporanic acid derivatives.
    Type: Grant
    Filed: July 6, 1981
    Date of Patent: August 23, 1983
    Assignee: Gist-Brocades N.V.
    Inventors: Cornelis A. Bruynes, Theodorus K. Jurriens
  • Patent number: 4384956
    Abstract: A novel process for the purification of waste water and/or waste water sludge comprising subjecting the waste water and/or waste water sludge to first a methane fermentation step, then a denitrification step and finally an oxidation step by aeration, the electron donor in the denitrification step being mainly the sulfide from the methane fermentation step and the remaining reduced compounds in the liquid effluent from the methane fermentation step being oxidized in the aeration step.
    Type: Grant
    Filed: November 3, 1981
    Date of Patent: May 24, 1983
    Assignee: Gist-Brocades N.V.
    Inventor: Arnold Mulder
  • Patent number: 4379923
    Abstract: A novel process for the preparation of 7-acylamino-3-(thio-substituted)-methyl-3-cephem-4-carboxylic acid 1-oxide derivatives comprising reacting a 7-acylamino-3-bromomethyl-3-cephem-4-carboxylic acid-1-oxide derivative with a silylated thiol of the formulaR--S--Si(CH.sub.3).sub.3 Iwherein R is an organic group, preferably a 5- or 6-membered heterocyclic group, which reaction is preferably carried out in the presence of an inert organic solvent at a temperature between -20.degree. and 80.degree. C. to obtain the corresponding 7-acylamino-3-(R-thiomethyl)-3-cephem-4-carboxylic acid-1-oxide derivatives, which are valuable intermediates in methods for the preparation of therapeutically active cephalosporins.
    Type: Grant
    Filed: August 28, 1981
    Date of Patent: April 12, 1983
    Assignee: Gist-Brocades N.V.
    Inventors: Cornelis A. Bruynes, Theodorus K. Jurriens
  • Patent number: 4366315
    Abstract: An improved process for the preparation of 3'-bromo-desacetoxycephalosphoranic acid sulfoxide compounds comprising protecting the 4-carboxy group of a 3'-unsubstituted cephalosporanic acid sulfoxide by silylating in an inert anhydrous organic solvent and brominating the silylated compound in situ which 3'-bromo compounds are valuable intermediates for the preparation of therapeutically useful cephalosporanic acid compounds.
    Type: Grant
    Filed: February 13, 1981
    Date of Patent: December 28, 1982
    Assignee: Gist-Brocades N.V.
    Inventors: Cornelis A. Bruynes, Theodorus K. Jurriens
  • Patent number: 4358438
    Abstract: A polyvalent virus vaccine for immunization of warm-blooded animals comprising a mixture of a rabies virus, preferably rabies strain No. 675 deposited in the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague under No. CNCTC No. A 04/77, and a canine distemper virus, said mixture being substantially free of material emanating from more than one type of tissue cell used to propagate the viruses and a process for its preparation by infecting a suitable single cell system with a rabies virus strain, propagating the rabies virus, infecting the cell system with at least one canine distemper virus, propagating the viruses and separating the polyvalent vaccine from the propagation product.
    Type: Grant
    Filed: April 13, 1981
    Date of Patent: November 9, 1982
    Assignee: Gist-Brocades N.V.
    Inventor: Gosse Bijlenga
  • Patent number: 4358588
    Abstract: A process for the preparation of [D-.alpha.-amino-p-hydroxyphenylacetamido]-penicillanic acid or cephalosporanic acid compounds comprising reacting a compound having a formula selected from the group consisting of ##STR1## wherein X is selected from the group consisting of hydrogen, acetoxy and five-membered heterocyclic group containing at least one hetero atom of the group consisting of oxygen, sulfur and nitrogen and optionally substituted with e.g. lower alkyl, this residue being attached to the 3-CH.sub.2 group via sulfur atom and wherein a NH radical if present has optionally been silylated with at least one mole equivalent of a silylating agent producing ##STR2## wherein R.sub.1, R.sub.2 and R.sub.
    Type: Grant
    Filed: October 3, 1980
    Date of Patent: November 9, 1982
    Assignee: Gist-Brocades N.V.
    Inventors: Peter W. Henniger, Johannes K. van der Drift, Gerard J. van Veen, Jagdish C. Kapur
  • Patent number: 4357320
    Abstract: Infectious bronchitis (IB) vaccines for poultry derived from at least one novel virus strain of novel infectious bronchitis serotypes, selected from the group consisting of culture Nos. CNCTC A 07/80, CNCTC A 08/80, CNCTC A 09/80, CNCTC A 010/80, CNCTC A 011/80, CNCTC A 013/80, CNCTC A 014/80, CNCTC A 015/80 and CNCTC A 016/80 deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague, Czechoslovakia and the novel viruses per se, combined virus vaccaines and a novel method of protecting poultry from infectious bronchitis.
    Type: Grant
    Filed: November 24, 1980
    Date of Patent: November 2, 1982
    Assignee: Gist-Brocades N. V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: 4351827
    Abstract: A polyvalent virus vaccine for immunization of warm-blooded animals comprising a mixture of a rabies virus, preferably rabies strain No. 675 deposited in the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague under No. CNCTC No. A 04/77, and a canine distemper virus, said mixture being substantially free of material emanating from more than one type of tissue cell used to propagate the viruses and a process for its preparation by infecting a suitable single cell system with a rabies virus strain, propagating the rabies virus, infecting the cell system with at least one canine distemper virus, propagating the viruses and separating the polyvalent vaccine from the propagation product.
    Type: Grant
    Filed: July 14, 1980
    Date of Patent: September 28, 1982
    Assignee: Gist-Brocades N.V.
    Inventor: Gosse Bijlenga
  • Patent number: 4348417
    Abstract: A process for the preparation of a novel potato snack product comprising mixing together a starch containing component, an active yeast, preferably baker's yeast, water and a sugar fermentable by the said yeast to form a dough mass, optionally dividing the dough into pieces, fermenting the dough mass or pieces for a period of time and temperature sufficient to form a light structure and frying in hot edible oil or fat or baking at ordinary oven temperatures the fermented dough or pieces to obtain a potato snack and the novel potato snacks formed thereby as well as a premix for said potato products.
    Type: Grant
    Filed: January 10, 1978
    Date of Patent: September 7, 1982
    Assignee: Gist-Brocades N.V.
    Inventors: Dirk H. Greup, Willem Brouwer
  • Patent number: RE31830
    Abstract: Infectious bronchitis (IB) vaccines for poultry derived from at least one novel virus strain of novel infectious bronchitis serotypes, selected from the group consisting of culture Nos. CNCTC A 07/80, CNCTC A 08/80, CNCTC A 09/80, CNCTC A 010/80, CNCTC A 011/80, CNCTC A 013/80, CNCTC A 014/80, CNCTC A 015/80 and CNCTC A 016/80 deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague, Czechoslovakia and the novel viruses per se, combined virus vaccaines and a novel method of protecting poultry from infectious bronchitis.
    Type: Grant
    Filed: March 18, 1983
    Date of Patent: February 12, 1985
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt