Patents Assigned to Gist-Brocades N.W. - Justia Patents Search

Patents Assigned to Gist-Brocades N.W.

Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them

Patent number: 5171844

Abstract: Novel polypeptides having Factor VIII activity are provided as well as compositions and methods for their preparation. The polypeptides comprise derivatives and fragments of Factor VIII and have sequences substantially similar to portions of naturally occuring Factor VIII. The polypeptides find use in treatment of Hemophilia A.

Type: Grant

Filed: June 10, 1988

Date of Patent: December 15, 1992

Assignee: Gist-Brocades N.W.

Inventors: Albert J. J. van Ooyen, Hans Pannekoek, Martinus P. Verbeet, Robert W. van Leen