Patents Assigned to GIST (Gwangju Institue of Science and Technology)
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Patent number: 4318852Abstract: The solvate of sodium amoxicillin and N-methyl-2-pyrrolidone and its preparation which is a stable antibiotic from which injectable solutions may be prepared.Type: GrantFiled: April 27, 1981Date of Patent: March 9, 1982Assignee: Gist-Brocades N.V.Inventors: Herwarth Heitman, Johannes K. van der Drift, Everardus J. A. M. Leenderts, Herman H. Grootveld
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Patent number: 4296769Abstract: A closure treatment machine having one or more caskets (1) for holding the closures (9); said caskets comprise a number of parallel bars (2, 3, 4), which are connected at both ends to each other by coupling plates (5, 6), whereby the parallel bars are arranged in such a way that the closures are held between said bars but still do have such a tolerance, that the cleansing liquid sprayed from nozzles (23) towards the closures may reach any side of the closures. For filling and emptying the caskets at least one of the coupling plates has an opening (7, 8) for passing the closures. The caskets which are moved by means of chains (16) may be led after a cleansing station to a drying station or a sterilization station.Type: GrantFiled: March 20, 1980Date of Patent: October 27, 1981Assignee: Gist-Brocades N.V.Inventor: Arie van der Lugt
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Patent number: 4282145Abstract: New azetidine derivatives of the formula: ##STR1## wherein R.sub.1 represents a penicillin- or cephalosporin-amido group, R.sub.2 represents one of the groups of the following formulae: ##STR2## wherein R.sub.4, R.sub.5 and R.sub.6 are the same or different and each represents a hydrogen atom or a lower alkyl or alkenyl group, n represents 2 or 3 and--in case formula IIB represents a phenyl group--this group may carry one to four further substituents selected from the group consisting of halogen atoms and lower alkyl, lower alkenyl and phenyl groups,R.sub.3 represents an amino group of the formula ##STR3## wherein R.sub.7 represents a hydrogen atom or a lower alkyl group and R.sub.8 represents a lower alkyl group, orR.sub.3 represents a N,N'-disubstituted hydrazino group wherein the substituents are lower alkyl groups, e.g. the N,N'-diisopropylhydrazino group, orR.sub.3 represents the group --OR.sub.9, wherein R.sub.Type: GrantFiled: October 21, 1975Date of Patent: August 4, 1981Assignee: Gist-Brocades N.V.Inventors: Jan Verwey, Hong S. Tan
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Patent number: 4267106Abstract: A process is disclosed for the preparation of 17.beta.-hydroxy-3-oxo-l7.alpha.-pregn-4-ene-21-carboxylic acid .gamma.-lactone and 17.beta.-hydroxy-3-oxo-17.alpha.-pregna-4,6-diene-21-carboxylic acid .gamma.-lactone of the formula: ##STR1## wherein the dotted line between the 6-7 positions indicates an optional double bond, which is present in the latter compound, by reacting an androst-5-ene-17-one derivative with an organo-phosphorus compound. These lactones are valuable intermediates in the synthesis of spironolactone.Type: GrantFiled: August 15, 1979Date of Patent: May 12, 1981Assignee: Gist Brocades N.V.Inventors: Arthur F. Marx, Peter M. Smid, Pieter Vellekoop
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Patent number: 4265894Abstract: Piperazine derivatives of the general formula ##STR1## wherein R.sub.1 -R.sub.9 are the same or different and each represents a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, n is 2 or 3 and X represents a group (CH.sub.2).sub.m (in which m is 1, 2, 3 or 4) or a group --CH.sub.2 --CH.dbd.CH--, having methylene linked to the piperazine group, and acid addition and quaternary ammonium salts thereof, are described.The compounds exhibit a strong specific dopaminergic activity.Also described are methods for their preparation and use as therapeutic agents in the form of therapeutic compositions.Type: GrantFiled: November 1, 1979Date of Patent: May 5, 1981Assignee: Gist Brocades, N.V.Inventor: Johan Gootjes
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Patent number: 4261183Abstract: A device for solidifying a layer of a liquid that solidifies upon cooling, such as agar, the liquid being contained in a row of petri-dishes or the like. The device utilizes a horizontally rotatable disc for receiving the dishes, a mechanism for supplying dishes to the disc, and a mechanism for removing the dishes, with solidified liquid, from the disc. A cooling mechanism is positioned below the disc to cool the disc and thereby cool the dishes. A mechanism is provided for slowly rotating the disc so that surfaces of materials in the dishes solidify in a non-rippled manner.Type: GrantFiled: October 4, 1979Date of Patent: April 14, 1981Assignee: Gist-Brocades N.V.Inventor: Ridderus W. Plomp
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Patent number: 4260743Abstract: Novel process for the preparation of .beta.-lactams of the formulae: ##STR1## wherein R' represents lower alkyl, aryl or aryl (lower alkyl), R" represents hydrogen or lower alkyl or R' and R" together with the carbon atoms to which they are attached represent lower cycloalkyl, R'" represents lower alkyl or a group --OR, wherein R represents lower alkyl, X.sub.1, Y.sub.1 and Z.sub.1 are hydrogen or selected organic radicals and R.sub.1 represents an acyl group; which successively involves reacting an 1,3-dicarbonyl compound of the formula: ##STR2## with glycine in the presence of a base to form a vinylamino salt of the formula: ##STR3## wherein M.sub.1.sup.+ is the cation of the base, activating the carboxyl group of said vinylamino salt with an appropriate activating agent and reacting the activated compound in the presence of a tertiary base with an imino compound of the formula: ##STR4## to form the corresponding .alpha.-vinylamino-.beta.-lactam of formula IV A and if desired, subjecting said .beta.Type: GrantFiled: December 31, 1979Date of Patent: April 7, 1981Assignee: Gist-Brocades N.V.Inventor: Ajay K. Bose
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Patent number: 4244941Abstract: Solid constant release composition wherein (a) the solution of soluble core substance within the core space remains saturated during dissolution and (b) the shape and (c) the surface of the coating and (d) the diffusion path for the soluble core substance through the porous coating remains constant while the composition is in a liquid medium, which composition is very useful in media in which constant release during substantially the whole release period is desired, for example, for medical, chemical and fermentation purposes.Type: GrantFiled: October 23, 1975Date of Patent: January 13, 1981Assignee: Gist-Brocades N.V.Inventor: Coenraad F. Lerk
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Patent number: 4242219Abstract: A novel process for preparing non-dusting, enzyme-containing particles, e.g. for introduction into washing compositions, comprising homogeneously mixing an amount of an enzyme in dry or substantially dry form to give the desired enzyme activity in the particles when formed, about 20% to about 60% of a hydrophilic organic cohesive compatible with the enzyme, about 10% to about 60% of a building agent suitable for use in enzyme compositions, and a sufficient amount of water, if necessary, to give a moisture content in the particles, when formed, of from 5% to 15%, mechanically dividing the mixture obtained into particles of the desired size, and coating the particles to prevent loss of moisture and the novel enzyme particles produced thereby as well as washing compositions and pharmaceutical compositions containing said enzyme particles.Type: GrantFiled: June 26, 1978Date of Patent: December 30, 1980Assignee: Gist-Brocades N.V.Inventors: Pieter K. Bogerman, Petrus J. Eygermans, Antoon G. van Velzen
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Patent number: 4217420Abstract: An active dried bakers' yeast is prepared with a dry matter content of at least 85% by weight, a protein content (%N.times.6.25) of 45 to 60% based on dry matter and an activity value of 420 to 600, when determined according to test method B.sup.2 as defined in the specification. The yeast has the advantages that it can be added as such to the flour prior to dough-making without preliminary soaking, and it is capable of better gas production than active dried yeasts hitherto available.Type: GrantFiled: September 18, 1978Date of Patent: August 12, 1980Assignee: Gist-Brocades N.V.Inventor: Arend Langejan
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Patent number: 4202896Abstract: Piperazine derivatives of the general formula ##STR1## wherein R.sub.1 -R.sub.9 are the same or different and each represents a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, n is 2 or 3 and X represents a group (CH.sub.2).sub.m (in which m is 1, 2, 3 or 4) or a group --CH.sub.2 --CH.dbd.CH--, having methylene linked to the piperazine group, and acid addition and quaternary ammonium salts thereof, are described.The compounds exhibit a strong specific dopaminergic activity.Also described are methods for their preparation and use as therapeutic agents in the form of therapeutic compositions.Type: GrantFiled: December 14, 1977Date of Patent: May 13, 1980Assignee: Gist-Brocades N.V.Inventor: Johan Gootjes
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Patent number: 4190670Abstract: Novel 18.xi.-, 19.xi.- and 20.xi.-hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxyl group and the group R.sub.4 are either in .alpha.- or .beta.-position and Z represents a --CH.sub.2 CH.sub.2 -- or a cis --CH.dbd.CH-- group, and wherein R represents one of the groups: ##STR2## (wherein the waved lines indicate that the hydroxyl groups are either in .alpha.- or .beta.-position and R.sub.1 represents a hydrogen atom, a methyl or ethyl group), R.sub.2 represents either an oxygen atom or a hydrogen atom and an .alpha.- or .beta.-hydroxyl group, R.sub.3 represents a hydrogen atom or a hydroxyl group and R.sub.4 represents a hydrogen atom or a methyl group, with the proviso that when simultaneously, R.sub.1, R.sub.3 and R.sub.4 each represents a hydrogen atom, R.sub.Type: GrantFiled: September 9, 1977Date of Patent: February 26, 1980Assignee: Gist Brocades N.V.Inventors: Arthur F. Marx, Jean Doodewaard
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Patent number: 4182870Abstract: An improved process for the preparation of 3-bromomethyl-3-cephem sulfoxide derivatives of the formula ##STR1## wherein R.sub.1 is an acylamido group and R.sub.2 is a group protecting the carboxy radical which are valuable intermediates for the preparation of various therapeutically useful cephalosporanic acid derivatives.Type: GrantFiled: August 30, 1978Date of Patent: January 8, 1980Assignee: Gist-Brocades N.V.Inventors: Cornelis A. Bruynes, Jan J. de Koning
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Patent number: 4177189Abstract: An improved process for the preparation in high yields of a compound of the formula ##STR1## wherein R is an optionally substituted phenyl group, Y is selected from the group consisting of Me and a hydrocarbon, Me is a metal cation and E is selected from the group consisting of hydrogen and a metal cation comprising reacting a compound of the formula ##STR2## wherein Q is selected from the group consisting of hydrogen and a silyl protecting group, Rz is an optionally substituted phenyl with the proviso that any hydroxy group present on the phenyl are replaced by --OQz, wherein Qz is a silyl protecting group and Ez is a carboxyl protecting group, with a compound of the formula ##STR3## wherein Z is a halogen and X is selected from the group consisting of OY and Z at low temperatures under anhydrous conditions and carefully hydrolyzing the resulting product either with just enough water to remove protecting groups and hydrolyze the Z groups to hydroxy groups and, still under anhydrous conditions, reacting the cType: GrantFiled: May 22, 1978Date of Patent: December 4, 1979Assignee: Gist-Brocades N.V.Inventors: Piet J. Akkerboom, Geertruiida J. Lower, Willem J. Timp
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Patent number: 4164446Abstract: Novel 18.xi.-, 19.xi.- and 20.xi.-hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxyl group and the group R.sub.4 are either in .alpha.- or .beta.-position and Z represents a --CH.sub.2 CH.sub.2 -- or a cis --CH.dbd.CH--group, and wherein R represents one of the groups: ##STR2## (wherein the waved lines indicate that the hydroxyl groups are either in .alpha.- or .beta.-position and R.sub.1 represents a hydrogen atom, a methyl or ehtyl group), R.sub.2 represents either an oxygen atom or a hydrogen atom and an .alpha.- or .beta.-hydroxyl group, R.sub.3 represents a hydrogen atom or a hydroxyl group and R.sub.4 represents a hydrogen atom or a methyl group, with the proviso that when simultaneously, R.sub.1, R.sub.3 and R.sub.4 each represents a hydrogen atom, R.sub.Type: GrantFiled: September 9, 1977Date of Patent: August 14, 1979Assignee: Gist Brocades N.V.Inventors: Arthur F. Marx, Jean Doodewaard
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Patent number: 4160829Abstract: 1,2,4-Oxadiazolylacetic acid derivatives. The derivatives include penicillin and cephalosporin amides which have antibiotic properties.Type: GrantFiled: May 9, 1977Date of Patent: July 10, 1979Assignee: Gist-Brocades N.V.Inventors: Robert Heijboer, Antoon VAN Harrewijn, Peter W. Henniger
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Patent number: 4155813Abstract: Fermentation process, e.g. for the production of an oxidation product such as vinegar, which comprises continuously cultivating a bacterial strain, preferably in a vessel of elongated shape, in a medium containing the substrate to be fermented in the presence of a hydrous oxide of a metal selected from the group consisting of titanium, vanadium, zirconium, iron and tin and a chelated polyhydroxy support. The bacterial strain used in the process is preferably chelated or complexed with the hydrous metal oxide and the polyhydroxy support.Type: GrantFiled: February 14, 1977Date of Patent: May 22, 1979Assignee: Gist-Brocades N.V.Inventors: Sidney A. Barker, Roderick N. Greenshields, John D. Humphreys, John F. Kennedy
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Patent number: RE30287Abstract: Novel 18 -, 19 - and 20 -hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxyl group and the group R.sub.4 are either in .alpha.- or .beta.-position and Z represents a --CH.sub.2 CH.sub.2 -- or a cis --CH.dbd.CH-- group, and wherein R represents one of the groups: ##STR2## (wherein the waved lines indicate that the hydroxyl groups are either in .alpha.- or .beta.-position and R.sub.1 represents a hydrogen atom, a methyl or ethyl group), R.sub.2 represents either an oxygen atom or a hydrogen atom and an .alpha.- or .beta.-hydroxyl group, R.sub.3 represents a hydrogen atom or a hydroxyl group and R.sub.4 represents a hydrogen atom or a methyl group, with the proviso that when simultaneously, R.sub.1, R.sub.3 and R.sub.4 each represents a hydrogen atom, R.sub.Type: GrantFiled: October 26, 1978Date of Patent: May 27, 1980Assignee: Gist-Brocades N.V.Inventors: Arthur F. Marx, Jean Doodewaard
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Patent number: RE30602Abstract: A novel enzyme having a high proteolytic activity in alkaline media and being suitable for inclusion in washing compositions and which is produced by a novel Bacillus strain designated "PB 92", or its proteolytic enzyme producing mutants or variants. A culture of the Bacillus is deposited with the Laboratory for Microbiology of the Technical University of Delft, The Netherlands, where it has been given number OR-60.Type: GrantFiled: December 30, 1977Date of Patent: May 5, 1981Assignee: Gist-Brocades N.V.Inventor: Bauke TeNijenhuis
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Patent number: RE30669Abstract: The production of a rennin of high milk coagulating activity and low proteolytic activity from a selected strain of Mucor miehei which is useful in cheese making.Type: GrantFiled: October 15, 1979Date of Patent: July 7, 1981Assignee: Gist-Brocades N.V.Inventor: Louis Feldman