Patents Assigned to GLADIUS PHARMACEUTICALS CORPORATION
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Patent number: 11028103Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.Type: GrantFiled: May 21, 2018Date of Patent: June 8, 2021Assignee: GLADIUS PHARMACEUTICALS CORPORATIONInventors: Larry D. Sutton, Sophia Yu
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Patent number: 10239890Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.Type: GrantFiled: May 29, 2018Date of Patent: March 26, 2019Assignee: Gladius Pharmaceuticals CorporationInventors: Larry Sutton, Sophia Yu
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Patent number: 10000509Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.Type: GrantFiled: November 9, 2017Date of Patent: June 19, 2018Assignee: Gladius Pharmaceuticals CorporationInventors: Larry Sutton, Sophia Yu
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Patent number: 9975905Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making betalactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.Type: GrantFiled: March 12, 2014Date of Patent: May 22, 2018Assignee: Gladius Pharmaceuticals CorporationInventors: Larry D. Sutton, Sophia Yu
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Patent number: 9862729Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.Type: GrantFiled: August 25, 2016Date of Patent: January 9, 2018Assignee: GLADIUS PHARMACEUTICALS CORPORATIONInventors: Larry Sutton, Sophia Yu
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Patent number: 9809605Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.Type: GrantFiled: July 21, 2017Date of Patent: November 7, 2017Assignee: GLADIUS PHARMACEUTICALS CORPORATIONInventors: Larry Sutton, Sophia Yu
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Patent number: 9453032Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.Type: GrantFiled: September 19, 2014Date of Patent: September 27, 2016Assignee: GLADIUS PHARMACEUTICALS CORPORATIONInventors: Larry Sutton, Sophia Yu