Abstract: A compressed tablet of a pharmaceutical compound which contains uncoated pellets containing a pharmaceutical compound, where the uncoated pellets are dispersed in a matrix containing the pellets and a swellable polymer.

Abstract: A method of coating spherical particles of a beta blocker compound which is based on (a) determining the surface area of a weighed sample of said spherical particles; (b) determining the weight of coating material per surface area unit of spherical particles that will provide a desired release profile for said beta-blocker; (c) determining the surface area of a subsequent batch of spherical particles containing the same beta; (d) coating the subsequent batch of spherical particles with the coating applied in step (b) to provide a coating having substantially the same weight of coating material per surface area unit of spherical particles as determined in step (b).

Abstract: The invention proves a novel compressed tablet of a pharmaceutical compound and a method of making a tablet of a pharmaceutical compound which are based on uncoated pellets containing a pharmaceutical compound that are dispersed in a matrix which comprises said pellets and a swellable polymer which is compressed into a tablet.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A central discharge assembly is provided at the lower end of the product containers for emptying particles from the machine.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. A nozzle ramp is provided around the nozzle. The nozzle ramp is generally cusp shaped and includes nozzle-ramp surface. The nozzle ramp is centrally positioned around the nozzle and is directed upwardly towards the partition so that the nozzle-ramp surface directs particles moving generally horizontally across the orifice plate from the down bed upwardly into the partition and the up bed. The nozzle ramp may further include air passages for passing fluidized air upwardly to the nozzle-ramp surface.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. The fluidized apparatus further includes a central first plenum located below the orifice plate and being aligned with the up-bed and the partition, the first plenum being sized and shaped to direct gas upwardly through the orifice plate and into the up-bed; and a second plenum located below the orifice plate positioned around the first plenum for directing gas upwardly through the orifice plate and into contact with particles located on the orifice plate.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A plurality of inwardly directed discharge jets are positioned along the periphery of the product container and generally adjacent to the orifice plate.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A plurality of inwardly directed discharge jets are positioned along the periphery of the product container and generally adjacent to the orifice plate.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A plurality of inwardly directed discharge jets are positioned along the periphery of the product container and generally adjacent to the orifice plate.

Abstract: A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A plurality of inwardly directed discharge jets are positioned along the periphery of the product container and generally adjacent to the orifice plate.

Abstract: A shield, such as an upstanding cylindrical partition, is mounted adjacent to an air source, such as an air distribution plate/screen of a Wurster system processor, whereby the open upper end of the partition is generally horizontally registered with and disposed about the upper extremity of an associated spray nozzle. The open lower end of the inner cylindrical partition is generally sealed relative to the air distribution plate/screen and operative to receive air upwardly therethrough for subsequent passing through the inner partition about the spray nozzle. The upper end of the inner tubular partition shields the initial spray pattern discharged from the spray nozzle and prevents the premature entrance of particles moving into the spray nozzle area.

Abstract: A fluidized bed apparatus having a downwardly opening filter housing and including multiple processing gas outlets and a partition structure dividing the interior of the filter housing into individual downwardly-opening open-bottom compartments equal in number to the gas outlets. The partition structure extends into an expansion chamber below the filter housing. The partition structure that divides the housing not only extends the full height of the filter housing portion, but projects appreciably downwardly therefrom into the upper portion of the expansion chamber disposed below the filter housing. Each gas outlet is associated with a filter cartridge mounted on a tubular fitting. The gas filter cartridge is tubular and filters the gas passing through each of the divided filter housing compartments.

Abstract: A shield, such as an upstanding cylindrical partition, is mounted adjacent to an air source, such as an air distribution plate/screen of a Wurster system processor, whereby the open upper end of the partition is generally horizontally registered with and disposed about the upper extremity of an associated spray nozzle. The open lower end of the inner cylindrical partition is generally sealed relative to the air distribution plate/screen and operative to receive air upwardly therethrough for subsequent passing through the inner partition about the spray nozzle. The upper end of the inner tubular partition shields the initial spray pattern discharged from the spray nozzle and prevents the premature entrance of particles moving into the spray nozzle area.