Abstract: A fluidized bed reactor for granulating and coating particles in very small amounts having an essentially conical product container, a filter housing with filters inserted above the product container, and a lower housing below the conical product container having a process air supply. The product container has a sieve bottom in the center of which is a height-adjustable two-component nozzle. At least one guide element associated with the sieve bottom directs at least part of the process air to the two-component nozzle in a radial manner.

Abstract: The invention relates to a flowable fibrin adhesive granulate containing thrombin, Factor XIII, fibrinogen, and a calcium salt in the form of granules with a particle size of more than 50 ?m to 1000 ?m. Said granulate is useful for the healing of wounds in surgery, tissue therapy and/or as supporting material for biological factors. The invention also relates to an effervescent granulate and an effervescent powder for producing a foam that is suitable for hemostasis. The invention further relates to preparations to arrest bleeding containing a non-woven fabric for wounds consisting of a biodegradable supporting material that is coated with a fibrin glue granulate mixture or mixed granulate.

Abstract: A fluidized bed reactor for granulating and coating particles in very small amounts having an essentially conical product container, a filter housing with filters inserted above the product container, and a lower housing below the conical product container having a process air supply. The product container has a sieve bottom in the center of which is a height-adjustable two-component nozzle. At least one guide element associated with the sieve bottom directs at least part of the process air to the two-component nozzle in a radial manner.

Abstract: A solid formulation of a fibrin tissue adhesive for use in medical procedures is disclosed. The formulation is a mixture containing thrombin and fibrinogen with factor XIII in a pourable solid granule form. The granules are obtained by drying the protein solutions or suspensions in a fluidized bed apparatus. Preferably, the granules have a particle size between 20 and 1,000 um.

Abstract: A solid formulation of a fibrin tissue adhesive for use in medical procedures is disclosed. The formulation is a mixture containing thrombin and fibrinogen with factor XIII in a pourable solid granule form. The granules are obtained by drying the protein solutions or suspensions in a fluidized bed apparatus. Preferably, the granules have a particle size between 20 and 1,000 um.