Patents Assigned to Glaxo Group Limited
  • SUBSTITUTED DIKETOPIPERAZINES AND THEIR USE AS OXYTOCIN ANTAGONISTS
    Publication number: 20130102783
    Abstract: Compounds of formula (1) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is 2-methyl-1,3-oxazol-4-yl and R4 and R5 together with the nitrogen atom to which they are attached represents morpholino, process for their preparation, pharmaceutical compositions containing them and their use in medicine.
    Type: Application
    Filed: December 14, 2012
    Publication date: April 25, 2013
    Applicant: GLAXO GROUP LIMITED
    Inventor: GLAXO GROUP LIMITED
  • Compounds which have activity at Mreceptor and their uses in medicine
    Patent number: 8426443
    Abstract: Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: April 23, 2013
    Assignee: Glaxo Group Limited
    Inventors: David Gwyn Cooper, Ian Thomson Forbes, Vincenzo Garzya, Dale James Johnson, Graeme Irvine Stevenson, Paul Adrian Wyman
  • NOVEL USE
    Publication number: 20130078198
    Abstract: This invention relates to the use of sodium dodecylbenzene sulphonate (SDDBS) for helping to prevent or remove surface deposited stains from natural teeth and dental prostheses and oral care compositions comprising SDDBS for such use.
    Type: Application
    Filed: March 22, 2011
    Publication date: March 28, 2013
    Applicant: GLAXO GROUP LIMITED
    Inventors: Gail Cameron Aitken, David Raymond Churchley
  • Dispensing device
    Patent number: 8397714
    Abstract: An inhaler is provided with a restricting member to prevent unintentional actuation of the inhaler. Also provided is an inhaler with an extensible strap joining a dust cap to the housing of an inhaler, the strap being particularly suited for use with inhalers that comprise a restricting member. The inhaler is useful, for example, in the treatment of asthma.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: March 19, 2013
    Assignee: Glaxo Group Limited
    Inventors: Allen John Pearson, Gregor John McLennan Anderson, Peter John Brand, Mark Anthony Cox, Ian Cude, Phillp William Farr, Andrew Michael Kelly, Daniel Thomas De Sausmarez Lintell, Paul Kenneth Rand
  • N-pyrazolyl carboxamides as CRAC channel inhibitors
    Patent number: 8399436
    Abstract: The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: March 19, 2013
    Assignee: Glaxo Group Limited
    Inventors: David George Allen, Diane Mary Coe, Anthony William James Cooper, Paul Martin Gore, David House, Stefan Senger, Steven Leslie Sollis, Sadie Vile, Caroline Wilson
  • Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
    Patent number: 8389802
    Abstract: Methods for amplification of nucleic acids in cells are provided. Also provided are cells that contain the nucleic acids.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: March 5, 2013
    Assignees: The Biological Research Center of the Hungarian Academy of Sciences, Glaxo Group Limited
    Inventors: Gyula Hadlaczky, Aladar A. Szalay
  • Heterocyclic compounds
    Patent number: 8389508
    Abstract: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: March 5, 2013
    Assignee: Glaxo Group Limited
    Inventors: Guanghui Deng, Xichen Lin, Feng Ren, Baowei Zhao
  • Tricyclic nitrogen containing compounds as antibacterial agents
    Patent number: 8389524
    Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials. Z1 and Z2 are independently selected from CH and N.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: March 5, 2013
    Assignee: Glaxo Group Limited
    Inventors: David Evan Davies, David Thomas Davies, Ilaria Giordano, Alan Joseph Hennessy, Neil David Pearson
  • 7-(lH-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS
    Publication number: 20130040984
    Abstract: The present invention relates to a compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast and/or basophil cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, chronic spontaneous urticaria and autoimmune conditions.
    Type: Application
    Filed: April 27, 2011
    Publication date: February 14, 2013
    Applicant: GLAXO GROUP LIMITED
    Inventors: Francis Louis Atkinson, Michael David Barker, Clement Douault, Neil Stuart Garton, John Liddle, Vipulkumar Kantibhai Patel, Alexander George Steven Preston, David Matthew Wilson
  • Machine and method for pharmaceutical and pharmaceutical-like product assembly
    Patent number: 8372225
    Abstract: A method and apparatus for assembling a plurality of independently formed solid components is provided thereby forming a single delivery vehicle for a pharmaceutical or pharmaceutical-like product. The solid components can be held and fed to the apparatus via a plurality of magazines. Pusher rods and the like can be used for positioning each of the solid components. Where the components are connected via a bonding liquid, a sprayer is provided and compression pins or the like press the components with the bonding liquid together to form the final product. A rivet or other connection structure can also be used and driven through holes in each of the solid components to form the final product.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: February 12, 2013
    Assignee: Glaxo Group Limited
    Inventors: Thomas Bailey, Ronnie Benditt, Nigel Brewerton, Steven D. Finkelmeier, Robert Glinecke, Luigi Martini, Paul Simmons
  • Substituted diketopiperazines as oxytocin antagonists
    Patent number: 8367673
    Abstract: A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a human in need thereof of an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: February 5, 2013
    Assignee: Glaxo Group Limited
    Inventors: Alan David Borthwick, Richard Jonathan Hatley, Deirdre Mary Bernadette Hickey, John Liddle, David George Hubert Livermore, Andrew McMurtrie Mason, Neil Derek Miller, Fabrizio Nerozzi, Steven Leslie Sollis, Anna Katrin Szardenings, Paul Graham Wyatt
  • COMPOUNDS
    Publication number: 20130030012
    Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 31, 2013
    Applicant: Glaxo Group Limited
    Inventors: Kai Long, Zehong Wan
  • MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
    Publication number: 20130030015
    Abstract: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
    Type: Application
    Filed: September 26, 2012
    Publication date: January 31, 2013
    Applicant: Glaxo Group Limited
    Inventors: Dramane I. LAINE, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
  • Immunoglobulins
    Patent number: 8362208
    Abstract: The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: January 29, 2013
    Assignee: Glaxo Group Limited
    Inventors: Stephanie Jane Clegg, Jonathan Henry Ellis, Volker Germaschewski, Paul Andrew Hamblin, George Kopsidas, Ruth McAdam, Rabinder Kumar Prinjha
  • Substituted diketopiperazines and their use as oxytocin antagonists
    Patent number: 8357685
    Abstract: Compounds of formula (1) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is 2-methyl-1,3-oxazol-4-yl and R4 and R5 together with the nitrogen atom to which they are attached represents morpholino, process for their preparation, pharmaceutical compositions containing them and their use in medicine.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: January 22, 2013
    Assignee: Glaxo Group Limited
    Inventor: John Liddle
  • Pyrazole derivatives used as CCR4 receptor antagonists
    Patent number: 8357716
    Abstract: Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: January 22, 2013
    Assignee: Glaxo Group Limited
    Inventors: Heather Hobbs, Simon Teanby Hodgson, Yannick Maurice LaCroix, Deborah Needham, Nigel James Parr, Panayiotis Alexandrou Procopiou, Timothy John Ritchie, Michael David Woodrow
  • 7,8-dihydropyrido[2,3-d]pyrimidin-4-yl substituted compounds as inhibitors of p38 kinase
    Patent number: 8354416
    Abstract: Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: January 15, 2013
    Assignee: Glaxo Group Limited
    Inventors: James F. Callahan, Jeffrey C. Boehm, Anthony William James Cooper, Stefano Livia, Paul Bamborough, Neysa Nevins, Zehong Wan, Beth A. Norton, Xichen Lin
  • Indole derivatives as IKK2 inhibitors
    Patent number: 8354539
    Abstract: The invention is directed to a certain novel compound which is an inhibitor of kinase activity, in particular IKK2 activity.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: January 15, 2013
    Assignee: Glaxo Group Limited
    Inventor: Qi Jin
  • PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS
    Publication number: 20130012491
    Abstract: Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis.
    Type: Application
    Filed: March 16, 2011
    Publication date: January 10, 2013
    Applicant: GLAXO GROUP LIMITED
    Inventors: Xichen Lin, Feng Ren, Haibo Zhang
  • Fluid dispensing device
    Patent number: 8347879
    Abstract: A fluid dispensing device is disclosed having a housing and a fluid discharge device. The fluid discharge device is arranged to be actuated by one or more levers so as to apply a force transversely to the fluid discharge device which is used to move a container forming part of the fluid discharge device along a longitudinal axis of the fluid discharge device to cause actuation of a pump forming part of the fluid discharge device. A pre-load means is used to prevent actuation of the pump until a pre-determined force is applied to each lever of sufficient magnitude to guarantee the production of a well developed efficient spray from the fluid dispensing device.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: January 8, 2013
    Assignee: Glaxo Group Limited
    Inventors: Michael Birsha Davies, James W. Godfrey