Abstract: The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, Alzheimer's disease, and type 2 diabetes.

Abstract: The present invention is directed to novel retinoid-related orphan receptor gamma (ROR?) modulators, processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by ROR?.

Abstract: Compounds of formula (I) wherein R1 is 2-indanyl, R2 is 1-methylpropyl, R3 is a group selected from 2,6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R4 represents methyl and R5 represents hydrogen or methyl or, R4 and R5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists.

Abstract: The present invention relates to a dentifrice composition comprising a stannous salt e.g., stannous fluoride and a water-soluble alkali metal tripolyphosphate e.g., sodium tripolyphosphate and a non-aqueous carrier and wherein the composition is substantially free of any water and does not comprise a source of zinc ions or an aqueous buffer system.

Abstract: A new pharmaceutical formulation for retinoid-containing soft gelatin capsules is disclosed. The new formulation comprises a soft gelatin capsule filled with a fill mass comprising a retinoid as an active ingredient, a natural vegetable oil, a partially hydrogenated natural vegetable oil and medium chain triglycerides. Optionally, the new formulation also comprises a natural wax. In a particularly preferred embodiment, the soft gelatin capsule comprises pig gelatin in the capsule shell in combination with the above fill mass.

Abstract: The invention relates to linkers suitable for use in antigen-binding proteins, certain antigen binding proteins and methods of making such proteins and uses thereof.

Abstract: A re-sealable flexible sachet (10, 50) with a nozzle portion (14) which is foldable about a fold line (41, 52, 110) to constrict the outlet conduit (15) when the nozzle portion (14) is in the folded configuration, and the nozzle portion (14) has an ear (20A, 20B, 51) extending in a transverse direction with a corresponding slot opening (23A, 23B, 53) to receive the ear (20A, 20B, 51) to secure the nozzle portion (14) when the nozzle portion (14) is in the folded configuration.

Abstract: The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease or Alzheimer's disease.

Abstract: A process for forming lactose suitable for use in a pharmaceutical formulation comprises providing a plurality of lactose particles containing no more than 10% w/w of lactose particles having a volume average particle size of about 70 microns or less; milling the plurality of lactose particles to yield a plurality of milled lactose particles with an average particle size, (D50), ranging from about 50 microns to about 100 microns; and classifying the plurality of milled lactose particles into at least two fractions comprising a fine fraction and a coarse fraction wherein the fine fraction has an average particle size, (D50), ranging from about 3 microns to about 50 microns, and the coarse fraction has an average particle size, (D50), ranging from about 40 microns to about 250 microns.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: The present invention relates to cephalosporin antibacterial compounds of Formula (I): or corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.

Abstract: A sheet driver for use in a medicament dispenser with blister pockets includes: (a) a base, extending from the base, (b) a shaft defining a rotational axis; at the base, (c) a drive surface for receipt of drive to rotate the base about the rotational axis; about the shaft, (d) a torsion spring defining first and second spring legs; mounting about the shaft and the torsion spring for rotation about the rotational axis, and (e) a hub defining a hub surface for receipt of a sheet of the medicament carrier, the hub surface being adapted to provide an initial effective winding surface which provides uniform indexing of the medicament carrier.

Abstract: A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicyclic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

Abstract: A dust cap for a pMDI having a cap part adapted for a push-fit on the dispensing nozzle of the pMDI and a strap part for connecting the dust cap to the pMDI, wherein the cap part is slidably mounted on the strap part for sliding movement between an extended position and a contracted position.

Abstract: There is provided a drug dispenser device comprising a housing defining a first chamber; extending from said housing and defining a second open chamber, an outlet for insertion into a body cavity of a patient; provided to said first chamber of the housing, a discharge block defining a discharge block orifice; receivable within the first chamber for movement therewithin, a drug discharge device, said drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from said container, wherein said discharge channel is receivable by said discharge block to enable discharge of said drug formulation via said discharge block orifice to said outlet; provided to the housing; and at least one finger operable member moveable to apply a force directly or indirectly to the drug discharge device for movement along the longitudinal axis towards the discharge block to actuate said discharge mechanism.

Abstract: The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.

Abstract: A fluid dispensing device for dispensing a fluid form medicament formulation having a viscosity of from 10 to 2000 mPa·s, is disclosed having a housing and a fluid discharge device. The fluid discharge device is arranged to be actuated by one or more levers, so as to apply a force to the fluid discharge device which is used to move a container forming part of the fluid discharge device, along a longitudinal axis of the fluid discharge device to cause actuation of a pump forming. A pre-load mechanism prevents actuation of the pump until a pre-determined force is applied to each lever of sufficient magnitude to guarantee the production of a well-developed, efficient spray from the fluid dispensing device.

Abstract: A dentifrice composition providing superior shine and polish, low RDA and effective whitening comprising a calcined aluminum oxide polishing agent, a water soluble condensed phosphate such as an alkali metal phosphate salt and an orally acceptable carrier or excipient is described. The composition is free of a silica abrasive.

Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

Abstract: The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.