Patents Assigned to Glaxo Inc.
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Patent number: 5457098Abstract: There are disclosed preparation and compounds of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or lower alkyl or taken together are a --CH.sub.2 -- group to form a cyclopropane ring.X is ##STR2## wherein R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are hydrogen or alkyl,p and q are independently either 0 or 1;R.sup.3 is alkyl, alkenyl, cycloalkyl, alkoxy, thiopyridyl, adamantyl, --NR.sup.9 R.sup.10 or --Ar--NR.sup.9 R.sup.10 whereinR.sup.9 and R.sup.10 are hydrogen or alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, adamantyl, aryl, benzyl, diphenylmethyl, norbornyl, or taken together with the nitrogen to form 4 to 8 atom heterocyclic group, ##STR3## optionally substituted with alkyl groups; Ar is aromaticR.sup.4 is hydrogen or methyl;Z is --O--, --NH--, --N(lower alkyl), --S--, --SO--, --SO.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, CO, CO.sub.2, O.sub.2 C, --N.dbd.N--, --CH.dbd.N--, or --N.dbd.CH--,and n and m are 0, 1 or 2.Type: GrantFiled: January 28, 1994Date of Patent: October 10, 1995Assignee: Glaxo Inc.Inventors: Stephen V. Frye, David Middlemiss, Francis G. Fang
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Patent number: 5442892Abstract: A pneumatic apparatus for withdrawing goods from defective blister packages on a blister packaging machine and comprising a pair of spaced-apart and laterally shiftable vacuum heads reciprocally mounted above the carrier strip between the detection station and the sealing station of the blister packaging machine so that when one head is in vertical registration with the carrier strip the other head is laterally offset from the carrier strip. Each vacuum head comprises a plurality of suction elements depending from the bottom thereof which are adapted to selectively engage a predetermined plurality of goods on the carrier strip.Type: GrantFiled: January 14, 1994Date of Patent: August 22, 1995Assignee: Glaxo Inc.Inventors: Henry K. Burns, III, Hubert E. Burns, Thomas P. DiNardo, James E. Ingram
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Patent number: 5426196Abstract: The present Invention includes synthetic steps and intermediates involved in the following reaction scheme a of converting compounds of Formula (II) to the diarylmethanes of Formula (I): ##STR1## wherein: Y is oxygen or sulfur;A, B, C, D, and E are carbon or 1, 2 or 3 of A, B, C, D, and E are independently nitrogen, and the others are carbon; andwhereinR.sup.1 through R.sup.10 are selected independently from the group consisting of: hydrogen, hydroxy, alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkyl alkyl, alkenyl, hydroxy alkyl, alkoxy alkyl, perhalo-alkyl, amino, nitro, nitrile, halo, carboxyl, sulfonyl, acyl, formyl, carbamoyl, trifluoromethyl, aminomethyl, azido, amido, hydrazino, aryl, aryloxy, heteroaryl, or aryl or heteroaryl, mono, di, or tri substituted with one or more hydrogen, hydroxy, alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.Type: GrantFiled: December 22, 1993Date of Patent: June 20, 1995Assignee: Glaxo Inc.Inventor: Francis G. Fang
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Patent number: 5421492Abstract: The present invention relates to an aerosol dispensing apparatus, more particularly to aerosol dispensing valves incorporating a controlled metered dispensing function wherein the metering chamber holding the next aerosolized dose is in fluidic communication with the reservoir allowing homogenous mixing of the next aerosolized dose to be dispensed.Type: GrantFiled: November 2, 1993Date of Patent: June 6, 1995Assignee: Glaxo Inc.Inventors: Lee A. Barger, Terence G. H. Bowyer, Ignatius L. Britto, Michael L. Franklin
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Patent number: 5415162Abstract: A breath-actuated dry powder medicament inhalator device having a housing and a conduit mounted within the housing defining an air passageway therethrough having an aperture in the sidewall thereof. A blister-type strip of sealed containers arranged in a matrix of rows and columns wherein the columns extend generally diagonally to the longitudinal axis of the strip is secured in a two-piece cage adapted for being rotatably mounted around the conduit of the inhalator device. Advancement means are provided for rotatably moving the two-piece cage and blister strip contained thereby in a generally helical pathway relative to the conduit so as to successively advance each of the sealed containers of the blister strip into registration with the conduit aperture.Type: GrantFiled: January 18, 1994Date of Patent: May 16, 1995Assignee: Glaxo Inc.Inventors: Robert A. Casper, Malcolm E. Taylor, Frank A. Leith, David H. Leith, Maryanne G. Boundy
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Patent number: 5407687Abstract: The present invention comprises a bi-layer, pharmaceutical tablet having one layer formulated for the immediate release (IR) of ranitidine and a second layer formulated for sustained release (SR) of ranitidine with the ratio of ranitidine in the IR layer to that in the SR in the range of from about 30:70 to about 60:40.Type: GrantFiled: February 22, 1994Date of Patent: April 18, 1995Assignee: Glaxo Inc.Inventors: Mark D. Coffin, Alan F. Parr
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Patent number: 5387688Abstract: Novel piperidinyl intermediates as set forth below wherein R, R.sup.1 and Ar are as set forth in the specification and W is either hydrogen or benzyloxycarbonyl. The intermediates are useful in the preparation of N-phenyl-N-(4-piperidinyl) amides having potent analgesic activity.Type: GrantFiled: December 11, 1992Date of Patent: February 7, 1995Assignee: Glaxo Inc.Inventors: Paul L. Feldman, Marcus F. Brackeen
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Patent number: 5380872Abstract: CCK modulators, e.g. agonists or antagonists, of the following formula (I): ##STR1## or a base-addtion salt thereof.Type: GrantFiled: July 14, 1992Date of Patent: January 10, 1995Assignee: Glaxo Inc.Inventors: Elizabeth E. Sugg, Milana Dezube, Gavin C. Hirst
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Patent number: 5376359Abstract: A method of making a stabilized aerosol drug formulation is disclosed, along with the formulations so produced and metered drug inhalers containing the same. The method comprises combining a solid particulate drug composition with a fluoropolymer in a liquid fluorocarbon aerosol propellant to form a stable suspension. Further stabilization can be achieved by cooling the suspension for a time and to a temperature sufficient to adsorb the fluoropolymer to the solid particulate drug composition in the liquid fluorocarbon aerosol propellant. Preferred propellants for carrying out the invention are 1,1,1,2-tetrafluoroethane, heptafluoropropane, and mixtures thereof, and preferred fluoropolymers for carrying out the invention are fluoropolyethers.Type: GrantFiled: July 7, 1992Date of Patent: December 27, 1994Assignee: Glaxo, Inc.Inventor: Keith A. Johnson
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Patent number: 5342947Abstract: The present invention relates to the synthesis of water soluble, camptothecin derivatives of formula (I), ##STR1## wherein: n represents the integer 1 or 2;R.sup.1 represents independently, hydrogen, lower alkyl, (C.sub.3-7)cycloalkyl, (C.sub.3-7)cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy lower alkyl; andR.sup.2 represents hydrogen andthe pharmaceutically acceptable salts thereof.Type: GrantFiled: October 9, 1992Date of Patent: August 30, 1994Assignee: Glaxo Inc.Inventors: Karen Lackey, Daniel D. Sternbach
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Patent number: 5329008Abstract: Synthesis of the triol of the following formula (I) from an alcohol of the formula (IV): ##STR1## via steps including protecting and then cyanating the alcohol to yield a cyanide, isomerization of the double bond, hydrolysis followed by reduction of the cyanide back to an alcohol and cis-dihydroxylation of the double bond.Type: GrantFiled: April 7, 1993Date of Patent: July 12, 1994Assignee: Glaxo Inc.Inventors: John J. Partridge, Brian L. Bray
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Patent number: 5326760Abstract: Aminobutanoic acids of the following formula (I): ##STR1## where R.sup.1 -R.sup.5 are a variety of substituents, novel intermediates, a pharmaceutical composition for treating inflammatory diseases, demyelinating diseases, and tumor metastasis, methods for such treatment and processes for preparing compounds of formula (I).Type: GrantFiled: March 15, 1993Date of Patent: July 5, 1994Assignee: Glaxo, Inc.Inventors: Andrew B. McElroy, Peter J. Brown, David H. Drewry, James M. Salovich, Frank J. Schoenen
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Patent number: 5318183Abstract: A bottle having an inserted tube in its neck to effectively reduce its interior volume and allow a large surface area for the bottle exterior, e.g. for supporting a large label or to allow oversized print, with a relatively small interior volume, e.g. to prevent abrasions caused by the interior contents moving excessively against each other.Type: GrantFiled: November 4, 1992Date of Patent: June 7, 1994Assignee: Glaxo, Inc.Inventors: Donald B. Cohen, Norris W. Matthews
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Patent number: 5318976Abstract: The present invention relates to certain substituted tetracyclic fused quinoline derivatives of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo, methoxy or amino;R.sup.2 is hydrogen, hydroxy, methoxy or amino;R.sup.3 is hydrogen, hydroxy, methoxy, methoxymethoxy, amino, --OCONH.sub.2, [2(5H)-3,4-dihydro-3-oxyfuranone], 2-hydroxyethoxy, 2-aminoethoxy, 3-hydroxypropoxy or 3-aminopropoxy; or taken together with R.sup.2 or R.sup.4, methylenedioxy or ethylenedioxy;R.sup.4 is hydrogen, hydroxy or amino;Z is --CH.sub.2 --, --O-- or --NH--; anda) X.sup.1 is hydrogen;X.sup.2 is hydrogen, hydroxy, fluoro, chloro, bromo, iodo or methoxy; andX.sup.3 is hydrogen or hydroxy; orb) X.sup.2 taken together with X.sup.3 is methylenedioxy or ethylenedioxy, and X.sup.1 is hydrogenor a pharmaceutically acceptable salt thereof provided that:i) at least one of R.sup.1 through R.sup.4 is other than hydrogen.Type: GrantFiled: August 18, 1992Date of Patent: June 7, 1994Assignee: Glaxo Inc.Inventors: Michael J. Luzzi, Jeffrey Besterman, Michael G. Evans, M. Ross Johnson, Milana Dezube, Salvatore Profeta, Jr.
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Patent number: 5302589Abstract: The present invention relates to certain substituted 17 .beta.-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 arei) independently hydrogen or lower alkyl and the bond between the carbons bearing R.sup.1 and R.sup.2 is a single or a double bond, orii) taken together are a --CH.sub.2 -- group to form a cyclopropane ring, and the bond between the carbons bearing R.sup.1 and R.sup.2 is a single bond;X is ##STR2## wherein R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently hydrogen or lower alkyl,p and q are independently either 0 or 1;R.sup.3 is lower alkyl, lower alkenyl, lower cycloalkyl, lower alkoxy, thiopyridyl, adamantyl, --NR.sup.9 R.sup.10 or --Ar--NR.sup.9 R.sup.10whereinR.sup.9 and R.sup.Type: GrantFiled: August 7, 1992Date of Patent: April 12, 1994Assignee: Glaxo, Inc.Inventors: Stephen V. Frye, David Middlemiss, Francis G. Fang
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Patent number: 5261538Abstract: The present invention comprises a method for measuring the amount, i.e., mass, of a volatile liquid which comprises passing the mass over a heat loss measuring device, calculating the amount of heat loss accompanying the vaporization of the mass and correlating the heat loss to measurement of heat loss of known liquid aerosol mass made with the same device.Type: GrantFiled: April 21, 1992Date of Patent: November 16, 1993Assignee: Glaxo Inc.Inventors: Rix E. Evans, Alec P. Flowers, Jr., David E. Hockaday, David W. Loar, James K. Proctor
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Patent number: 5258519Abstract: Compounds of the following formula (I): ##STR1## where R.sup.1 and R.sup.2 are alkyl or cycloalkyl, which may be substituted, R.sup.4 is aryl such as phenyl which may be substituted, L is a direct bond or an oxygen containing linking group, R is a hydrogen, alkyloxy, alkyl, halogen or haloalkyl and Het is a pyridinyl or pyridazinyl group. The compounds can be used antihypertensives or myocardial relaxants. Also part of the invention are pharmaceutical compositions, intermediates and methods of synthesis.Type: GrantFiled: December 10, 1991Date of Patent: November 2, 1993Assignee: Glaxo Inc.Inventors: Thomas N. Wheeler, Terrence P. Kenakin
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Patent number: 5252560Abstract: Compounds are described of the formula ##STR1## wherein: R.sup.1 is C.sub.3-6 alkyl or C.sub.1-3 alkylthioC.sub.1-3 alkyl;R.sup.2 is an optionally substituted C.sub.1-6 alkyl or C.sub.1-6 alkoxy group, aryl, heteroaryl, arylC.sub.1-4 alkyl, heteroarylC.sub.1-4 alkyl or a side-chain of a natural .alpha.-amino acid;R.sup.3 is hydrogen, C.sub.1-6 alkyl, CHR.sup.4 COR.sup.5 (where R.sup.4 is a side-chain of a natural .alpha.-amino acid and R.sup.5 is hydroxyl, C.sub.1-6 alkoxy or NHR.sup.6 where R.sup.6 represents a hydrogen atom or a C.sub.1-6 alkyl group) or a group (CH.sub.2).sub.n X (where n is 1 to 6 and X is hydroxyl, C.sub.1-4 alkoxy, heteroaryl or a group NR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are each hydrogen or C.sub.1-6 alkyl or the group NR.sup.7 R.sup.Type: GrantFiled: June 29, 1992Date of Patent: October 12, 1993Assignee: Glaxo Inc.Inventors: Peter L. Myers, Andrew B. McElroy, Michael Gregson, Peter J. Brown, Howard G. Davies, David H. Drewry, Michael A. Foley
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Patent number: 5241069Abstract: This invention relates to the new process for preparing the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-pur in-6-one, an antiviral agent and intermediates of the formula (Vlb) use in that process ##STR1## wherein X is chloro, bromo or iodo and R is (C.sub.1-6) alkyl.Type: GrantFiled: November 6, 1991Date of Patent: August 31, 1993Assignees: Glaxo Inc., Univeristy of MinnesootaInventors: Robert Vince, Mark L. Peterson, John W. Lackey, Robert A. Mook, Jr., John J. Partridge
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Patent number: 5239993Abstract: A breath actuated dry powder medicament inhalator has a primary air passageway therethrough defining a venturi in the medial portion thereof. A secondary air passageway is provided which includes a compound deaggregating swirl chamber and is fluidly connected to the venturi of the primary air passageway. A dry powder compound storage chamber and cooperatively associated metering plate act to introduce a predetermined amount of compound into the swirl chamber upon actuation of the metering plate. The primary air passageway is configured within the inhalator apparatus so as to create an optimized air flow trajectory through the mouth of the user to minimize dry powder compound impingement upon the outside radius of the throat.Type: GrantFiled: August 26, 1992Date of Patent: August 31, 1993Assignee: Glaxo Inc.Inventor: Rix E. Evans