Patents Assigned to Glaxo Wellcome House
  • METHODS OF INCREASING YIELDS OF PLEUROMUTILINS
    Publication number: 20130017608
    Abstract: This invention relates to a novel Pleuromutilin gene cluster and methods of increasing yields of Pleuromutilin produced by Clitopilus and related basidiomycete species.
    Type: Application
    Filed: October 28, 2010
    Publication date: January 17, 2013
    Applicant: Glaxo Wellcome House
    Inventors: Andrew Mark Bailey, Gatherine Collins, Amanda Crawford, Gary Foster, Alison Michelle Griffin, Sreedhar Kilaru, Angela Scrogham, David Spence
  • OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS
    Publication number: 20120283297
    Abstract: Oxadiazole substituted indazole derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.
    Type: Application
    Filed: December 16, 2010
    Publication date: November 8, 2012
    Applicant: GLAXO WELLCOME HOUSE
    Inventors: James Bailey, Nigel Paul King, Xichen Lin, Feng Ren, Kheng-Chuan Tan, Sing Yeung Mak
  • THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS
    Publication number: 20120094979
    Abstract: Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptor are disclosed.
    Type: Application
    Filed: June 17, 2010
    Publication date: April 19, 2012
    Applicant: Glaxo Wellcome House
    Inventors: James Matthew Bailey, Emmanuel Hubert Demont, Xichen Lin, Feng Ren, Christian Alan Paul Smethurst
  • Novel Compounds
    Publication number: 20090111866
    Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.
    Type: Application
    Filed: April 18, 2007
    Publication date: April 30, 2009
    Applicant: Glaxo Wellcome House
    Inventors: Keith Biggadike, Anthony William James Cooper, David House, Iain McFarlane McLay, Grahame Robert Woollam
  • Deracemisation of amines
    Publication number: 20060257978
    Abstract: The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method.
    Type: Application
    Filed: March 19, 2003
    Publication date: November 16, 2006
    Applicant: Glaxo Wellcome House
    Inventors: Marina Alexeeva, Alexis Enright, Mahmoud Mahmoudian, Nicholas Turner