Patents Assigned to Glaxo Wellcome Inc. Research
  • Altered antibodies and their preparation
    Patent number: RE43898
    Abstract: An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species.
    Type: Grant
    Filed: September 16, 1991
    Date of Patent: January 1, 2013
    Assignee: Glaxo Wellcome Inc. Research
    Inventors: Scott David Gorman, Michael Ronald Clark, Stephen Paul Cobbold, Herman Waldmann