Patents Assigned to GlaxoSmithKline Biologicals, S.R.
  • Polyanionic polymer adjuvants for haemophilus influenzae B saccharide vaccines
    Patent number: 8007818
    Abstract: The present invention relates to the field of vaccines, and in particular vaccines comprising antigens of low isoelectric point at pH 7.0, in particular the capsular polysaccharide or oligosaccharide of H. influenzae B (PRP). Immunogenic compositions and methods of making such compositions are presented in which the PRP is surprisingly protected from immune interference by adding a polyanionic polymer (such as PLG-poly-L-glutamic acid) to the composition.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: August 30, 2011
    Assignee: GlaxoSmithKline Biologicals, S.R.
    Inventors: Nathalie Marie-Josephe Garcon, Dominique Lemoine, Florence Emilie Jeanne Francoise Wauters