Abstract: The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domains, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.
Type:
Application
Filed:
August 12, 2011
Publication date:
August 8, 2013
Applicant:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Inventors:
Haren Arulanantham, Thil Dinuk Batuwangala, Elena De Angelis, Carolyn Enever, Haiqun Liu, Oliver Schon
Abstract: A method of producing a metering valve for use with a pressurised dispensing container for dispensing medicament from said container, the metering valve having a valve stem, a valve member, and outer and inner annular seals, the method comprising assembling the metering valve so that the valve stem is co-axially slidable within the valve member, the valve member and the valve stem define an annular metering chamber with a surface of the valve member forming an internal surface of the metering chamber which, in use, comes into contact with medicament, and the outer and inner annular seals are operative between respective outer and inner ends of the valve member and the valve stem to seal the annular metering chamber therebetween; and wherein the method further comprises the step of subjecting said surface of the valve member to a cold plasma polymerisation treatment of one or more monomers to bond to the surface a layer of a cold plasma polymerised fluorinated hydrocarbon.
Type:
Application
Filed:
February 27, 2013
Publication date:
July 4, 2013
Applicant:
GlaxoSmithKline Intellectual Property Development Limited
Inventor:
GlaxoSmithKline Intellectual Property Development Limited
Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.
Type:
Application
Filed:
September 6, 2011
Publication date:
June 27, 2013
Applicant:
GlaxoSmithKline Intellectual Property Development Limited
Inventors:
Julie Nicole Hamblin, Paul Spencer Jones, Suzanne Elaine Keeling, Joelle Le, Charlotte Jane Mitchell, Nigel James Parr, Robert David Willacy
Abstract: The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
Type:
Application
Filed:
September 6, 2011
Publication date:
June 27, 2013
Applicant:
GlaxoSmithKline Intellectual Property Development Limited
Inventors:
Ian Robert Baldwin, Kenneth David Down, Paul Faulder, Simon Gaines, Julie Nicole Hamblin, Zoe Alicia Harrison, Katherine Louise Jones, Paul Spencer Jones, Suzanne Elaine Keeling, Joelle Le, Christopher James Lunniss, Charlotte Jane Mitchell, Nigel James Parr, Timothy John Ritchie, John Edward Robinson, Juliet Kay Simpson, Christopher Alan Paul Smethurst, Yoshiaki Washio