Patents Assigned to GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED
  • Thienopyridine NOX2 inhibitors
    Patent number: 9029545
    Abstract: The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase II enzyme.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: May 12, 2015
    Assignee: GlaxoSmithKline Intellectual Property Limited
    Inventors: Deborah Chen, Kiew Ching Lee, Lamont Roscoe Terrell
  • Compounds
    Patent number: 8877742
    Abstract: The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: November 4, 2014
    Assignee: GlaxoSmithKline Intellectual Property Limited
    Inventors: Deborah W. Chen, Sarah Duncan, Nigel Paul King, Kiew Ching Lee, Sing Yeung Mak, Dean Andrew Rivers
  • Pharmaceutical combination of pazopanib and topotecan to treat neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human
    Patent number: 8709420
    Abstract: The present invention relates to methods of treating neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a neuroblastoma treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 29, 2014
    Assignee: GlaxoSmithKline Intellectual Property Limited
    Inventors: Rakesh Kumar, Sylvain Baruchel
  • Combination
    Publication number: 20130303560
    Abstract: The present invention relates to a method of treating breast cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a breast cancer treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof.
    Type: Application
    Filed: January 31, 2012
    Publication date: November 14, 2013
    Applicants: SUNNYBROOK RESEARCH INSTITUTE, GLAXOSMITHKLINE INTELLECTUAL PROPERTY LIMITED
    Inventors: Rakesh Kumar, Robert S. Kerbel