Patents Assigned to GLAXOSMITHKLINE S.A.
  • Publication number: 20100047287
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Application
    Filed: November 3, 2009
    Publication date: February 25, 2010
    Applicants: GLAXOSMITHKLINE S.A., UTRECHT UNIVERSITY
    Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefsen, Johannes Petrus Maria Tommassen