Patents Assigned to Glen Research Corporation
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Patent number: 8394948Abstract: Novel CE-phosphoramidites and CPG reagents have been synthesized from a serinol backbone. These reagents are useful to introduce functional groups or directly label oligonucleotides. The versatile serinol scaffold allows for labeling at any position (5? or 3? termini, or any internal position) during automated DNA synthesis. Multiple labels or functional groups can be achieved by repetitive coupling cycles. Optimal spacer arms and protected label moieties have been specially designed. Further, the natural 3-carbon atom internucleotide phosphate distance is retained when inserted internally.Type: GrantFiled: September 28, 2010Date of Patent: March 12, 2013Assignees: Glen Research Corporation, Nelson Biotechnologies, Inc.Inventors: Paul S. Nelson, Hugh Mackie, Andrew Murphy
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Publication number: 20110077389Abstract: Novel CE-phosphoramidites and CPG reagents have been synthesized from a serinol backbone. These reagents are useful to introduce functional groups or directly label oligonucleotides. The versatile serinol scaffold allows for labeling at any position (5? or 3? termini, or any internal position) during automated DNA synthesis. Multiple labels or functional groups can be achieved by repetitive coupling cycles. Optimal spacer arms and protected label moieties have been specially designed. Further, the natural 3-carbon atom internucleotide phosphate distance is retained when inserted internally.Type: ApplicationFiled: September 28, 2010Publication date: March 31, 2011Applicants: Nelson Biotechnologies, Inc., Glen Research CorporationInventors: Paul S. Nelson, Hugh Mackie, Andrew Murphy
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Patent number: 7491817Abstract: Universal supports for oligonucleotide synthesis include a support material represented by the following formula: In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric or silica base material; substituent B is selected from acyl, aroyl, or a polymeric or silica base material; and substituent C is selected from a dimethoxytrityl group or a protecting group removable under acidic or neutral conditions. For the supports, one of substituents A or B constitutes the polymeric or silica base material. In use, an oligonucleotide is attached to the support at substituent C.Type: GrantFiled: May 24, 2004Date of Patent: February 17, 2009Assignee: Glen Research CorporationInventors: Alex Azhayev, Maxim Antopolskii
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Patent number: 7144995Abstract: A fluorescent nitrogenous base and nucleosides including the fluorescent nitrogenous base are provided. Nucleosides including the fluorescent nitrogenous base are capable of Watson-Crick base pairing with naturally occurring nucleosides. The nucleosides including the fluorescent nitrogenous base have many uses including but not limited to use in probes, in the synthesis of nucleic acids, and in investigating nucleic acid interactions with other nucleic acids and/or with proteins.Type: GrantFiled: March 6, 2003Date of Patent: December 5, 2006Assignees: Glen Research Corporation, Berry & AssociatesInventors: Dean S. Wise, Anthony D. Sercel, Kee-Yong Jung, David A. Berry, John B. Randolph, Robert L. Somers, Hugh Mackie
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Publication number: 20050250116Abstract: Universal supports for oligonucleotide synthesis include a support material represented by the following formula: In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric or silica base material; substituent B is selected from acyl, aroyl, or a polymeric or silica base material; and substituent C is selected from a dimethoxytrityl group or a protecting group removable under acidic or neutral conditions. For the supports, one of substituents A or B constitutes the polymeric or silica base material. In use, an oligonucleotide is attached to the support at substituent C.Type: ApplicationFiled: May 24, 2004Publication date: November 10, 2005Applicant: Glen Research CorporationInventors: Alex Azhayev, Maxim Antopolskii
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Publication number: 20040054161Abstract: A support for peptide-oligonucleotide conjugate synthesis includes an article of manufacture according to the formula: 1Type: ApplicationFiled: September 13, 2002Publication date: March 18, 2004Applicant: Glen Research CorporationInventors: Maxim Antopolskii, Elena Azhayeva, Alex Azhayev
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Publication number: 20040009933Abstract: A fluorescent nitrogenous base and nucleosides including the fluorescent nitrogenous base are provided. Nucleosides including the fluorescent nitrogenous base are capable of Watson-Crick base pairing with naturally occurring nucleosides. The nucleosides including the fluorescent nitrogenous base have many uses including but not limited to use in probes, in the synthesis of nucleic acids, and in investigating nucleic acid interactions with other nucleic acids and/or with proteins.Type: ApplicationFiled: March 6, 2003Publication date: January 15, 2004Applicants: Glen Research Corporation, Berry & AssociatesInventors: Dean S. Wise, Anthony D. Sercel, Kee-Yong Jung, David A. Berry, John B. Randolph, Robert L. Somers, Hugh Mackie
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Publication number: 20020137855Abstract: Universal supports for oligonucleotide synthesis include a support material represented by the following formula: 1Type: ApplicationFiled: November 29, 2001Publication date: September 26, 2002Applicant: Glen Research CorporationInventors: Alex Azhayev, Maxim Antopolskii
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Patent number: 5959090Abstract: Phosphoramidite building blocks according to the following formula 1 are used for phosphorylating oligonucleotides, preferably at the 5'- or 3'-terminus. The building blocks include phosphoramidite compounds according to formula 1: ##STR1## wherein DMTr is a 4,4'-dimethoxytrityl group; R.sub.1 is an electron withdrawing group; R.sub.2 is an electron withdrawing group which may be the same or different from the R.sub.1 group; R.sub.3 is an alkyl group; and R.sub.4 is an alkyl group which may be the same or different from the R.sub.3 group. Preferred electron withdrawing groups include --CO.sub.2 Et groups, --CO.sub.2 Me groups, --CN groups, --CON(Me).sub.2 groups, and --CONHMe groups, wherein Et represents an ethyl group and Me represents a methyl group. One preferred alkyl group is an isopropyl group.Type: GrantFiled: July 1, 1997Date of Patent: September 28, 1999Assignee: Glen Research CorporationInventors: Andrei Guzaev, Alex Azhayev, Harri Lonnberg