Abstract: Provided is a process for the preparation of linagliptin of Formula I, comprising deprotecting a compound of Formula II wherein R1 and R2 together with the nitrogen to which they are attached form a phthalimido group, wherein the aromatic ring of the phthalimido group is substituted with one or more R3 substituents selected from the group consisting of halogen, alkyi, nitro and amino; or R1 is H and R2 is selected from the group consisting of trialkylsilyl, 2-trialkylsilylethoxycarbamates, acetyl, trihaloacetyl, 9-fluorenylmethoxycarbonyl, trityl, alkylsulfonyl, arylsulfonyl, diphenylphosphine and sulfonylethoxycarbonyl.
Abstract: The present invention provides a process for preparation of fingolimod, a compound of Formula I or a pharmaceutically acceptable salt thereof, free of regioisomeric impurity compound of Formula IA.
Abstract: The present invention provides a process for the preparation of substituted 3?-hydrazino-biphenyl-3-carboxylic acid compounds. The present invention further provides a process for the preparation of 3?-{N?-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2?-hydroxybiphenyl-3-carboxylic acid, its intermediate compounds and pharmaceutically acceptable salts thereof.
Type:
Application
Filed:
September 12, 2012
Publication date:
March 26, 2015
Applicant:
Glenmark Generics Limited
Inventors:
Bhargav Krishnaji Upadhye, Shivaji Eknath Jagadale, Mukesh Soni
Abstract: The present invention provides a process for preparation of fingolimod, a compound of Formula I or a pharmaceutically acceptable salt thereof, free of regioisomeric impurity compound of Formula IA
Abstract: The present invention provides novel palonosetron free base in an amorphous form and crystalline form-G and processes for their preparation. The present invention also provides a process for the preparation of palonosetron hydrochloride from the novel palonosetron free base in an amorphous form and/or in crystalline form-G.
Type:
Grant
Filed:
December 11, 2008
Date of Patent:
November 6, 2012
Assignee:
Glenmark Generics Limited
Inventors:
Mubeen Khan, Mahendra Patil Raghunath, Prashant Yadav Kundlik
Abstract: An aqueous gel composition of the present invention comprising about 0.1 to 0.3 wt % adapalene and about 2.5 to 5.0 wt % benzoyl peroxide, as active ingredients, wherein both the active ingredients are stabilized in hydrophilic gelling matrix of pH dependent gelling agent comprising crosslinked, acrylic acid-based polymer(s).
Type:
Application
Filed:
March 23, 2012
Publication date:
October 4, 2012
Applicant:
Glenmark Generics Limited
Inventors:
Kamal Mehta, Lalatendu Panigrahi, Uday Kumar Nayak, Balakrishna Patro
Abstract: The present invention provides a process for preparation of racemic voriconazole in a single reaction vessel. The present invention also provides a process for preparation of voriconazole using racemic voriconazole and the process of making it therewith.
Type:
Application
Filed:
February 4, 2010
Publication date:
December 22, 2011
Applicant:
GLENMARK GENERICS LIMITED
Inventors:
Francis Paul D'Souza, Premkumar Ramraj Yadav, Shankar Sanganabhatla, Mubeen Ahmed Khan
Abstract: The present invention provides novel solid milnacipran in crystalline form-G and a process for its preparation. The present invention also provides a process for the preparation of milnacipran hydrochloride from the novel solid crystalline milnacipran.
Type:
Application
Filed:
July 6, 2009
Publication date:
October 28, 2010
Applicant:
Glenmark Generics Limited
Inventors:
Joseph Prabahar KOILPILLAI, Pravin Chhaburao THOMBRE, Sudam Nanabhau SINARE, Mubeen Ahmed KHAN
Abstract: The present invention relates to a process for the preparation of esomeprazole magnesium dihydrate, specifically, esomeprazole magnesium crystalline dihydrate form A; and pharmaceutical compositions thereof.
Type:
Application
Filed:
July 8, 2009
Publication date:
October 21, 2010
Applicant:
Glenmark Generics Limited
Inventors:
Joseph Prabahar KOILPILLAI, Pravin Bhalchandra Kulkami, Avikumar Digambar Dabe, Mubeen Ahmed Khan