Abstract: The present invention relates to a dry powder inhaler for administering a medicament via oral inhalation route to a subject. Particularly, the dry powder inhaler according to present invention is suitable for delivering accurate doses of a medicament in different ranges of inspiratory capacity of the subject.
Type:
Application
Filed:
May 23, 2019
Publication date:
September 12, 2019
Applicant:
GLENMARK PHARMACEUTICALS LIMITED
Inventors:
Ulhas DHUPPAD, Rachel Rachel STRIEBIG, Scott Alexander LEWIS, Matthew David ALLEN, Lai Chiu TANG, Stuart Robert ABERCROMBIE, John William Sanford HALE, Thomas Stephen COLLINGS
Abstract: The present invention relates to a dry powder inhaler for administering a medicament via oral inhalation route to a subject. Particularly, the dry powder inhaler according to present invention is suitable for delivering accurate doses of a medicament in different ranges of inspiratory capacity of the subject.
Type:
Grant
Filed:
December 23, 2014
Date of Patent:
July 23, 2019
Assignee:
GLENMARK PHARMACEUTICALS LIMITED
Inventors:
Ulhas Dhuppad, Rachel Victoria Striebig, Scott Alexander Lewis, Matthew David Allen, Lai Chiu Tang, Stuart Robert Abercrombie, John William Sanford Hale, Thomas Stephen Collings
Abstract: The present invention relates to a process for the preparation of ospemifene and pharmaceutically acceptable salts thereof which comprises the step of recycling the undesired E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol to generate an isomeric mixture of Z,E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol.
Abstract: The present invention relates to a process for the preparation of dimethyl fumarate, a compound of formula I, in a purity of at least 99.0% as determined by HPLC, containing less than 400 ppm of an anion of a mineral acid and less than 5 ppm of dimethyl maleate.
Type:
Grant
Filed:
September 22, 2014
Date of Patent:
December 12, 2017
Assignee:
GLENMARK PHARMACEUTICALS LIMITED
Inventors:
Shekhar Bhaskar Bhirud, Kumar Hari Bhushan, H M Veerabhadra Swamy, Dilipkumar Jibhau Patil, Avikumar Digambar Dabe
Abstract: The present invention provides a process for the preparation of linagliptin, a compound of Formula I, the process comprising deprotecting a compound of Formula II wherein R1 and R2 together with the nitrogen to which they are attached form a phthalimido group, wherein the aromatic ring of the phthalimido group is substituted with one or more R3 substituents selected from the group consisting of halogen, alkyl, nitro and amino; or R1 is H and R2 is selected from the group consisting of trialkylsilyl, 2-trialkylsilylethoxycarbamates, acetyl, trihaloacetyl, 9-fluorenylmethoxycarbonyl, trityl, alkylsulfonyl, arylsulfonyl, diphenylphosphine and sulfonylethoxycarbonyl.
Abstract: Provided is an improved process for the preparation of arformoterol L-(+)-tartrate, and more specifically provided is a novel process for the preparation of arformoterol L-(+)-tartrate via arformoterol D-(?)-tartrate.
Abstract: The present invention provides a process for the preparation of substituted 3?-hydrazino-biphenyl-3-carboxylic acid compounds. The present invention further provides a process for the preparation of 3?-{N?-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo -1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2?-hydroxybiphenyl-3-carboxylic acid, its intermediate compounds and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
September 12, 2012
Date of Patent:
September 13, 2016
Assignee:
Glenmark Pharmaceuticals Limited
Inventors:
Bhargav Krishnaji Upadhye, Shivaji Eknath Jagadale, Mukesh Soni
Abstract: Provided is a process for the preparation of linagliptin of Formula I, comprising deprotecting a compound of Formula II wherein R1 and R2 together with the nitrogen to which they are attached form a phthalimido group, wherein the aromatic ring of the phthalimido group is substituted with one or more R3 substituents selected from the group consisting of halogen, alkyi, nitro and amino; or R1 is H and R2 is selected from the group consisting of trialkylsilyl, 2-trialkylsilylethoxycarbamates, acetyl, trihaloacetyl, 9-fluorenylmethoxycarbonyl, trityl, alkylsulfonyl, arylsulfonyl, diphenylphosphine and sulfonylethoxycarbonyl.