Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
Abstract: The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
Type:
Grant
Filed:
April 17, 2001
Date of Patent:
August 7, 2007
Assignee:
Gliamed, Inc.
Inventors:
Yong-Qian Wu, Wei Huang, Gregory S. Hamilton
Abstract: The present invention provides methods for promoting healing of a wound in a and for promoting regeneration of epithelial tissue in a subject comprising administering an effective amount of 2,2?-(1,3,4-oxadiazole-2,5-diyl)bis[1-(3,3-dimethyl-1,2-dioxopentyl)-pyrrolidine (GM-284).
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