Abstract: The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H.sub.3 -receptor antagonists. Such compounds have affinity for histamine H.sub.3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H.sub.3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.
Type:
Grant
Filed:
October 29, 1993
Date of Patent:
January 23, 1996
Assignees:
The University of Toledo, Gliatech, Inc.
Inventors:
Graham J. Durant, Amin M. Khan, Clark E. Tedford