Patents Assigned to GLOBAL BIOENERGIES
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Patent number: 12258312Abstract: The present application relates to a compound of the following formula (I) in which —R1, R2, R3 and R4 represent independently of each other H or a (C1-C30) alkyl group, the total sum of the number of carbon atoms of R1, R2, R3 and R4 being equal to 6+4x, x being a whole number of between 1 and 6, provided that: at most two of the groups R1, R2, R3 and R4 are H, R5 represents H, OR, or NR?R? R, R? and R?, identical or different, represent H, a (C1-C10) alkyl group, at least one of groups R1, R2, R3 or R4 comprises or is a tertiobutyl group. (I) the method for preparing same and the uses thereof as a plasticising lubricant, surfactant or in a cosmetic composition.Type: GrantFiled: August 17, 2020Date of Patent: March 25, 2025Assignee: Global BioenergiesInventors: Serge Ratton, Marc Lemaire, Luc Mathis, Estelle Metay
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Patent number: 12084704Abstract: Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein the enzymatic conversion of 3-methylcrotonic acid into isobutene is achieved by making use of an FMN-dependent decarboxylase associated with an FMN prenyl transferase, wherein said FMN prenyl transferase catalyzes the prenylation of a flavin cofactor (FMN or FAD) utilizing dimethylallyl phosphate (DMAP) into a flavin-derived cofactor, wherein said method further comprises providing said DMAP enzymatically by: (i) the enzymatic conversion of dimethylallyl pyrophosphate (DMAPP) into said DMAP; or (ii) a single enzymatic step in which prenol is directly enzymatically converted into said DMAP; or (iii) two enzymatic steps comprising: first enzymatically converting DMAPP into prenol; and then enzymatically converting the thus obtained prenol into said DMAP; or (iv) the enzymatic conversion of isopentenyl monophosphate (IMP) into said DMAP, or by a combination of any one of (i) tType: GrantFiled: April 19, 2018Date of Patent: September 10, 2024Assignee: Global BioenergiesInventors: Romain Chayot, Mathieu Allard, Maria Anissimova
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Patent number: 11773421Abstract: Described is a method for the production of fructose-6-phosphate (F6P) from dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P) comprising the steps of: (a) enzymatically converting dihydroxyacetone phosphate (DHAP) into dihydroxyacetone (DHA); and (b) enzymatically converting the thus produced dihydroxyacetone (DHA) and glyceraldehyde-3-phosphate (G3P) into fructose-6-phosphate (F6P); or comprising the steps of: (a?) enzymatically converting glyceraldehyde-3-phosphate (G3P) into glyceraldehyde; and (b?) enzymatically converting the thus produced glyceraldehyde together with dihydroxyacetone phosphate (DHAP) into fructose-1-phosphate (F1P); and (c?) enzymatically converting the thus produced fructose-1-phosphate (F1P) into fructose-6-phosphate (F6P).Type: GrantFiled: July 26, 2019Date of Patent: October 3, 2023Assignee: Global BioenergiesInventors: Alfredo Alarcon Yanez, Samia Boudah, Romain Chayot
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Publication number: 20220112532Abstract: Described is a method for the production of fructose-6-phosphate (F6P) from dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P) comprising the steps of: (a) enzymatically converting dihydroxyacetone phosphate (DHAP) into dihydroxyacetone (DHA); and (b) enzymatically converting the thus produced dihydroxyacetone (DHA) and glyceraldehyde-3-phosphate (G3P) into fructose-6-phosphate (F6P); or comprising the steps of: (a?) enzymatically converting glyceraldehyde-3-phosphate (G3P) into glyceraldehyde; and (b?) enzymatically converting the thus produced glyceraldehyde together with dihydroxyacetone phosphate (DHAP) into fructose-1-phosphate (F1P); and (c?) enzymatically converting the thus produced fructose-1-phosphate (F1P) into fructose-6-phosphate (F6P).Type: ApplicationFiled: July 26, 2019Publication date: April 14, 2022Applicant: Global BioenergiesInventors: Alfredo Alarcon Yanez, Samia Boudah, Romain Chayot
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Patent number: 11293016Abstract: Described are 3-methylcrotonic acid decarboxylase (MDC) variants showing an improved activity in converting 3-methylcrotonic acid into isobutene as well as methods for the production of isobutene using such enzyme variants.Type: GrantFiled: September 23, 2020Date of Patent: April 5, 2022Assignee: Global BioenergiesInventors: François Stricher, Benoît Villiers
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Patent number: 11261438Abstract: Described are mevalonate diphosphate decarboxylase variants having improved activity in converting 3-phosphonoxyisovalerate into isobutene. Such variants can be employed in processes for biologically producing isobutene from 3-hydroxyisovalerate or from 3-hydroxy-3-methylbutyrate into isobutene, for biologically producing isoprenol from mevalonate or from mevalonate-3-phosphate or for biologically producing 1,3-butadiene from 3-hydroxypent-4-enoate or from 3-phosphonoxypent-4-enoate. Also described is an enzyme which is characterized in that it is capable of converting 3-phosphonoxyisovalerate into isobutene with a kcat of more than 0.1 s?1.Type: GrantFiled: July 9, 2014Date of Patent: March 1, 2022Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Sabine Mazaleyrat, Marc Delcourt, Maria Anissimova, Philippe Marliere
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Publication number: 20210403956Abstract: Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-methylcrotonyl-CoA into 3-methylcrotonic acid or wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-hydroxyisovalerate (HIV) into 3-methylcrotonic acid. It is described that the enzymatic conversion of 3-methylcrotonic acid into isobutene can, e.g., be achieved by making use of a 3-methylcrotonic acid decarboxylase, preferably an FMN-dependent decarboxylase associated with an FMN prenyl transferase, an aconitate decarboxylase (EC 4.1.1.6), a methylcrotonyl-CoA carboxylase (EC 6.4.1.4), or a geranoyl-CoA carboxylase (EC 6.4.1.5).Type: ApplicationFiled: June 29, 2021Publication date: December 30, 2021Applicants: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Mathieu Allard, Maria Anissimova, Philippe Marlière
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Patent number: 11162120Abstract: Described is a method for the enzymatic production of an acyl phosphate from a 2-hydroxyaldehyde using a phosphoketolase or a sulfoacetaldehyde acetyltransferase.Type: GrantFiled: September 8, 2016Date of Patent: November 2, 2021Assignees: Scientist of Fortune, S.A., Global BioenergiesInventor: Philippe Marlière
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Patent number: 11124806Abstract: Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-methylcrotonyl-CoA into 3-methylcrotonic acid or wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-hydroxyisovalerate (HIV) into 3-methylcrotonic acid. It is described that the enzymatic conversion of 3-methylcrotonic acid into isobutene can, e.g., be achieved by making use of a 3-methylcrotonic acid decarboxylase, preferably an FMN-dependent decarboxylase associated with an FMN prenyl transferase, an aconitate decarboxylase (EC 4.1.1.6), a methylcrotonyl-CoA carboxylase (EC 6.4.1.4), or a geranoyl-CoA carboxylase (EC 6.4.1.5).Type: GrantFiled: November 17, 2016Date of Patent: September 21, 2021Assignees: Global Bioenergies, Scientist of Fortune, SAInventors: Mathieu Allard, Maria Anissimova, Philippe Marlière
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Publication number: 20210277425Abstract: Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein the enzymatic conversion of 3-methylcrotonic acid into isobutene is achieved by making use of an FMN-dependent decarboxylase associated with an FMN prenyl transferase, wherein said FMN prenyl transferase catalyzes the prenylation of a flavin cofactor (FMN or FAD) utilizing dimethylallyl phosphate (DMAP) into a flavin-derived cofactor, wherein said method further comprises providing said DMAP enzymatically by: (i) the enzymatic conversion of dimethylallyl pyrophosphate (DMAPP) into said DMAP; or (ii) a single enzymatic step in which prenol is directly enzymatically converted into said DMAP; or (iii) two enzymatic steps comprising: first enzymatically converting DMAPP into prenol; and then enzymatically converting the thus obtained prenol into said DMAP; or (iv) the enzymatic conversion of isopentenyl monophosphate (IMP) into said DMAP, or by a combination of any one of (i) tType: ApplicationFiled: April 19, 2018Publication date: September 9, 2021Applicant: Global BioenergiesInventors: Romain Chayot, Mathieu Allard, Maria Anissimova
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Patent number: 10988752Abstract: Described are 3-methylcrotonic acid decarboxylase (MDC) variants showing an improved activity in converting 3-methylcrotonic acid into isobutene as well as methods for the production of isobutene using such enzyme variants.Type: GrantFiled: July 3, 2019Date of Patent: April 27, 2021Assignee: Global BioenergiesInventors: François Stricher, Benoît Villiers
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Publication number: 20210102186Abstract: Described are 3-methylcrotonic acid decarboxylase (MDC) variants showing an improved activity in converting 3-methylcrotonic acid into isobutene as well as methods for the production of isobutene using such enzyme variants.Type: ApplicationFiled: September 23, 2020Publication date: April 8, 2021Applicant: Global BioenergiesInventors: François Stricher, Benoît Villiers
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Patent number: 10941423Abstract: Described is a method for the production isoamyl alcohol (3-methylbutan-1-ol) comprising the enzymatic conversion of 3-methylbutyryl-CoA (isovaleryl-CoA) into isoamyl alcohol comprising: (a) two enzymatic steps comprising (i) first the enzymatic conversion of 3-methylbutyryl-CoA into 3-methylbutyraldehyde (3-methylbutanal or isovaleraldehyde); and (ii) then enzymatically converting the thus obtained 3-methylbutyraldehyde into said isoamyl alcohol; or (b) a single enzymatic reaction in which 3-methylbutyryl-CoA is directly converted into isoamyl alcohol by making use of an alcohol-forming short chain acyl-CoA dehydrogenase/fatty acyl-CoA reductase or an alcohol-forming fatty acyl-CoA reductase (long-chain acyl-CoA:NADPH reductase) (EC 1.2.1.84). Further, described is the above method wherein the 3-methylbutyryl-CoA can be provided by the enzymatic conversion of 3-methylcrotonyl-CoA into said 3-methylbutyryl-CoA.Type: GrantFiled: June 23, 2016Date of Patent: March 9, 2021Assignee: Global BioenergiesInventors: Maria Anissimova, Mathieu Allard
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Patent number: 10808237Abstract: Described are 3-methylcrotonic acid decarboxylase (MDC) variants showing an improved activity in converting 3-methylcrotonic acid into isobutene as well as methods for the production of isobutene using such enzyme variants.Type: GrantFiled: October 5, 2018Date of Patent: October 20, 2020Assignee: Global BioenergiesInventors: François Stricher, Benoît Villiers
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Patent number: 10676765Abstract: Described is a method for the conversion of 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyric acid comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyryl-CoA; and (b) further enzymatically converting the thus produced 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid wherein the enzymatic conversion of 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid according to step (b) is achieved by first converting 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyryl phosphate and then subsequently converting the thus produced 3-hydroxy-3-methylbutyryl phosphate into 3-hydroxy-3-methylbutyric acid.Type: GrantFiled: September 16, 2015Date of Patent: June 9, 2020Assignee: Global BioenergiesInventors: Philippe Marlière, Maria Anissimova, Mathieu Allard
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Publication number: 20200010858Abstract: Described is a method for the production isoamyl alcohol (3-methylbutan-1-ol) comprising the enzymatic conversion of 3-methylbutyryl-CoA (isovaleryl-CoA) into isoamyl alcohol comprising: (a) two enzymatic steps comprising (i) first the enzymatic conversion of 3-methylbutyryl-CoA into 3-methylbutyraldehyde (3-methylbutanal or isovaleraldehyde); and (ii) then enzymatically converting the thus obtained 3-methylbutyraldehyde into said isoamyl alcohol; or (b) a single enzymatic reaction in which 3-methylbutyryl-CoA is directly converted into isoamyl alcohol by making use of an alcohol-forming short chain acyl-CoA dehydrogenase/fatty acyl-CoA reductase or an alcohol-forming fatty acyl-CoA reductase (long-chain acyl-CoA:NADPH reductase) (EC 1.2.1.84). Further, described is the above method wherein the 3-methylbutyryl-CoA can be provided by the enzymatic conversion of 3-methylcrotonyl-CoA into said 3-methylbutyryl-CoA.Type: ApplicationFiled: June 23, 2016Publication date: January 9, 2020Applicant: Global BioenergiesInventors: Maria Anissimova, Mathieu Allard
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Publication number: 20190322996Abstract: Described are 3-methylcrotonic acid decarboxylase (MDC) variants showing an improved activity in converting 3-methylcrotonic acid into isobutene as well as methods for the production of isobutene using such enzyme variants.Type: ApplicationFiled: July 3, 2019Publication date: October 24, 2019Applicant: Global BioenergiesInventors: François Stricher, Benoît Villiers
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Patent number: 10407669Abstract: Described are HIV kinase variants showing an improved activity in converting 3-hydroxyisovalerate (HIV) into 3-phosphonoxyisovalerate (PIV), methods for the production of PIV using such enzyme variants as well as methods for the production isobutene in a subsequent reaction.Type: GrantFiled: July 27, 2016Date of Patent: September 10, 2019Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Sabine Mazaleyrat, Jean-Baptiste Barbaroux, Marc Delcourt, Francois Stricher, Philippe Marlière
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Patent number: 10364418Abstract: Described are 3-hydroxyisovalerate (HIV) synthase variants having improved activity in converting acetone and a compound which provides an activated acetyl group into 3-hydroxyisovalerate (HIV). Moreover, described are in particular methods for the production of 3-hydroxyisovalerate and methods for the production of isobutene from acetone utilizing the HIV synthase variants of the present invention.Type: GrantFiled: December 17, 2014Date of Patent: July 30, 2019Assignees: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Philippe Marliére, Marc Delcourt, Sabine Mazaleyrat, Jean-Baptiste Barbaroux
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Publication number: 20190112620Abstract: Described is a method for the production of isobutene from 3-methylcrotonyl-CoA comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyric acid; and (b) further enzymatically converting the thus produced 3-methylbutyric acid into isobutene. The conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3-methylcrotonyl-CoA into 3-methyl butyryl-CoA and further enzymatically converting the thus produced 3-methylbutyryl-CoA into 3-methylbutyric acid. Alternatively, the conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3-methylcrotonyl-CoA into 3-methylcrotonic acid and then further enzymatically converting the thus produced 3-methylcrotonic acid into 3-methylbutyric acid.Type: ApplicationFiled: March 22, 2017Publication date: April 18, 2019Applicants: Global Bioenergies, Scientist of Fortune, S.A.Inventors: Mathieu Allard, Philippe Marlière