Patents Assigned to GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
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Patent number: 11969701Abstract: The system and method of the invention pertains to an axial flux stator is implemented to replace the drive-end magnets and the drive motor. The axial flux stator comprises a control circuit to control the voltage and current provided to the stator, to measure the torque and speed of rotation, and to measure the magnetic flux and magnetic flux density produced by the axial flux stator and impeller magnets, individually or in combination. The axial flux stator comprises a plurality of current carrying elements to produce magnetic flux in an axial direction and drive the impeller.Type: GrantFiled: November 28, 2020Date of Patent: April 30, 2024Assignee: Global Life Sciences Solutions USA LLCInventors: James Pellegrino Alexander, Klaus Gebauer, David Allan Torrey, Ashraf Said Atalla, Sima Didari, Richard Lee Damren
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Publication number: 20240132826Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.Type: ApplicationFiled: December 29, 2023Publication date: April 25, 2024Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11966988Abstract: The present disclosure relates to a system and method (10) for monitoring a set-up for manufacture and/or setting up for manufacture and/or tearing down after manufacture of a biopharmaceutical product. The method comprises: processing (S2, S3, S4) at least one image of a scene comprising the set-up for manufacture of the biopharmaceutical product. The processing of the at least one image comprises performing (S2) a first process on the at least one image for classifying first objects in the image, said first objects being devices such as clamps, pumps, valves and/or sensors and/or any other bio processing equipment. The first process comprising identifying, localizing and classifying the first objects in the image. A second process is performed (S3) on the at least one image for identifying and localizing connections in the images.Type: GrantFiled: November 12, 2019Date of Patent: April 23, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Hanish Lakhani, Nishu Garg, Hemalatha J
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Publication number: 20240117290Abstract: In an embodiment, a bioprocessing method includes securing a vessel containing a fluid to a platform capable of pivoting about a first axis, heating the fluid in the vessel while the platform is in a static, substantially upright position to facilitate a first bioprocessing procedure within the vessel. The method further includes pivoting the platform and vessel about the first axis to create a rocking motion to facilitate a second bioprocessing procedure within the vessel.Type: ApplicationFiled: October 4, 2022Publication date: April 11, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: MOJTABA PARVIZI, CRAIG MIZZONI, MACKENZIE RYAN
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Publication number: 20240121372Abstract: A bioreactor system includes a housing configured to house and support a vessel, a stereo camera having first and second imagers secured to the housing, the stereo camera configured to image a surface of a liquid and a foam exposed to a headspace of the vessel. The system further includes a controller operatively connected to the stereo camera and the stereo camera and controller are configured to create an image of the exposed surface and identify foam on the surface based on the image.Type: ApplicationFiled: October 7, 2022Publication date: April 11, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventor: ALAN STOCKDALE
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Publication number: 20240102882Abstract: A method for assessing the integrity of a bioprocessing system includes the steps of determining a mass of a first container, transferring a volume of fluid from the first container to a second container, determining the mass of the second container, comparing the mass of the first container with the mass of the second container, and, if the difference between the mass of the first container and the mass of the second container exceeds a threshold, generating a notification indicating that a leak is present.Type: ApplicationFiled: December 14, 2021Publication date: March 28, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: ANDREU FONTOVA SOSA, KASHAN ALI SHAIKH, PANTELEIMON ZOTOS
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Publication number: 20240093137Abstract: A sparger assembly for a bioprocessing system includes a base and a plurality of spargers connected to the base, each sparger including a plurality of pores, the plurality of spargers each have a generally cylindrical shape. Each of the plurality of spargers includes a sidewall and a top, which define the cylindrical shape, the sidewall and the top each include a plurality of pores. The pores of the sidewall can be arranged around a circumference of the sidewall at an array of heights. Ridges may also be located on the sidewall above a respective array of pores.Type: ApplicationFiled: September 19, 2022Publication date: March 21, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventor: RAFAEL DIANA
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Patent number: 11932842Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.Type: GrantFiled: February 8, 2019Date of Patent: March 19, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11920119Abstract: A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.Type: GrantFiled: February 8, 2019Date of Patent: March 5, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11905508Abstract: This present invention provides means for cell harvesting and isolation to be carried out with a single apparatus. This represents a more convenient way for the processing of cells compared with known methods and represents a useful development for the manufacture of cell therapies.Type: GrantFiled: December 14, 2018Date of Patent: February 20, 2024Assignee: Global Life Sciences Solutions USA LLCInventor: Trevor Smith
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Publication number: 20240034971Abstract: A method of bioprocessing includes the steps of providing a bioreactor vessel having a gas-permeable, liquid impermeable membrane, initiating a flow of gas, and passing the flow of gas across a bottom surface of the membrane to induce a turbulent interaction between the flow of gas and the membrane.Type: ApplicationFiled: December 14, 2021Publication date: February 1, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: ANDREU FONTOVA SOSA, MARK TIMMINS
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Publication number: 20240026272Abstract: A rocking mechanism for a bioreactor vessel includes a base, a motor mounted to the base and having an eccentric roller driven by the motor, and a rocking plate in contact with the eccentric roller, the rocking plate being configured to receive a bioreactor vessel thereon. The motor is controllable to drive the eccentric roller to transmit a force against an underside of the rocking plate to tilt the rocking plate and bioreactor vessel.Type: ApplicationFiled: December 14, 2021Publication date: January 25, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: ANDREU FONTOVA SOSA, MAGNUS GRAHN, NICOLAS PETITFOURG
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Publication number: 20240026274Abstract: A foam identification system including a thermal imaging camera and a controller connected to the thermal imaging camera. The thermal imaging camera images a surface of a liquid in a vessel that is exposed to a headspace of the vessel. The headspace being either warmer or cooler than the liquid. The camera and the controller detect a change in temperature of the exposed surface of the liquid to identify foam on the exposed surface of the liquid.Type: ApplicationFiled: July 22, 2022Publication date: January 25, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: JEFFREY SOCHA, ALAN STOCKDALE, DANIEL STELLA
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Patent number: 11879903Abstract: The present invention provides improved methods, facilities and systems for parallel processing of biological cellular samples in an efficient and scalable manner. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods, facilities and systems of the invention find particular utility in processing patient samples for use in cell therapy.Type: GrantFiled: November 23, 2020Date of Patent: January 23, 2024Assignee: Global Life Sciences Solutions USA LLCInventors: Firman Ghouze, Philip Vanek
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Publication number: 20240018453Abstract: A bioprocessing apparatus includes a flexible bag having an interior volume configured to contain a fluid, and an integral fluid conduit within the flexible bioprocessing bag. The integral fluid conduit includes a panel of material joined to an interior sidewall of the flexible bag so as to define a fluid channel between the interior sidewall of the flexible bag and the panel of material. The integral fluid conduit may include a bottom outlet opening, a top outlet opening, or both. The apparatus may further include a port in a top of the flexible bag, a port in the bottom of the flexible bag, or both, wherein the integral fluid conduit is fluidly connected to the ports.Type: ApplicationFiled: October 28, 2021Publication date: January 18, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventor: HANNA-LEENA SAUKKONEN
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Publication number: 20240018456Abstract: A bioprocessing apparatus includes a housing, a process drawer receivable within the housing and moveable between a closed position and an open position, the process drawer being configured to receive at least one culture vessel therein, and a cabinet positioned in stacked vertical relation to the housing, the cabinet including at least one vertical storage drawer slidably received within the cabinet.Type: ApplicationFiled: December 14, 2021Publication date: January 18, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: MARK TIMMINS, ANDREU FONTOVA SOSA, ROBERT CURTIS, KEITH BENOIT, DONALD FRASER, FERNANDO FRAGA, DENNIS CHEROK, NICOLAS PETITFOURG, ANDREW MALLOY, PHIL RAWLINS
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Publication number: 20240018457Abstract: A method for bioprocessing includes the steps of providing a bioprocessing system having a first bioreactor vessel and a second bioreactor vessel, activating a population of cells in the first bioreactor vessel, genetically modifying the population of cells to produce a population of genetically modified cells, and expanding the population of genetically modified cells within the first bioreactor vessel and the second bioreactor vessel.Type: ApplicationFiled: December 14, 2021Publication date: January 18, 2024Applicants: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC, KITE PHARMA, INC.Inventors: PANTELEIMON ZOTOS, YARDEN SIVAN GRATCH, ISABELLE DALLE FUSINE, KASHAN ALI SHAIKH, ALICJA MARIA KROL, NATE W. FREUND, ERWIN V. CAMMAART, ANTHONY P. SWANDA
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Publication number: 20240010966Abstract: An apparatus for magnetic cell isolation includes a base, a stopcock manifold interface located on the base and configured to receive a stopcock manifold of a cell processing kit, a magnetic field generator located within the base, and a slot formed in the base, the slot configured to removably receive a magnetic cell isolation holder. The magnetic field generator is movable into and out of engagement with the magnetic cell isolation holder.Type: ApplicationFiled: December 14, 2021Publication date: January 11, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: YORICK HEIMBERG, OLIVIER MARTI, THOMAS MERMOD, BENOIT DUBATH, JULIEN CAMISANI
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Publication number: 20240002777Abstract: A kit for magnetic cell isolation includes first stopcock manifold having at least four stopcocks, a separation chamber configured for use with a centrifugal processing chamber of the cell processing device, the separation chamber in fluid communication with the first stopcock manifold, a mixing bag configured for use with a heating/cooling mixing chamber of a cell processing device, the mixing bag in fluid communication with the first stopcock manifold, a second stopcock manifold having at least four stopcocks, the second stopcock manifold in fluid communication with the first stopcock manifold, a magnetic cell isolation holder in fluid communication with the second stopcock manifold, the magnetic cell isolation holder configured for use with a magnetic field generator of a magnetic cell isolation device, and a plurality of cell processing bags in fluid communication with the first and/or second stopcock manifolds.Type: ApplicationFiled: December 14, 2021Publication date: January 4, 2024Applicants: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC, KITE PHARMA, INC.Inventors: PIERRE-YVES CHASSOT, OLIVER LINK, FEDERICO ZANONI, MARK TIMMINS, KASHAN ALI SHAIKH, MARINE DE LAGENESTE, DENNIS CHEROK, YANN THOUEMENT, YORICK HEIMBERG, BERTRAND FOUCAUT, JULIEN CAMISANI, KENT YOUNG, SIMON GARDINER, ANTHONY P. SWANDA
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Publication number: 20240002775Abstract: A method for assessing the integrity of a bioprocessing system includes the steps of utilizing a pump of a bioprocessing system, pressurizing a plurality of flow lines, and measuring a decay of a pressure within the plurality of flow lines for a predetermined a duration.Type: ApplicationFiled: December 14, 2021Publication date: January 4, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: ANDREU FONTOVA SOSA, KASHAN ALI SHAIKH, PANTELEIMON ZOTOS, MARK TIMMINS