Abstract: The current invention concerns a cell medium for in vitro inducing chondrogenesis or tenogenesis in mesenchymal stem cells (MSCs). The medium includes a glucose medium supplemented with at least one growth factor. The growth factor is selected from fibroblast growth factors (FGF) or transforming growth factors (TGF). FGF or TGF is present in a total concentration of between 1 and 15 ng/ml. In both cases, IGF can be added to enhance the induction process. In a further aspect, the invention provides for a use of such cell medium as well as a method for inducing isolated mesenchymal stem cells (MSCs) and a cell composition obtained by such method.
Type:
Grant
Filed:
December 6, 2013
Date of Patent:
October 13, 2020
Assignee:
Global Stem Cell Technology
Inventors:
Sarah Yolande Kristel Broeckx, Jan Hilda Marie Jozef Spaas