Abstract: Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed.
Type:
Application
Filed:
August 12, 2009
Publication date:
December 10, 2009
Applicants:
GLOBELMMUNE, INC., THE REGENTS OF THE UNIVERSITY OF COLORADO
Inventors:
RICHARD C. DUKE, DONALD BELLGRAU, ALEX FRANZUSOFF, CARA C. WILSON